B cell aplasia and hypogammaglobulinemia associated with levetiracetam.

Ann Saudi Med

Hulya Ozdemir, Department of Pediatric Immunology and Allergy,, Medical Faculty, Selcuk University,, Alaeddin Keykubat Campus,, 42130 Selcuklu/Konya, Turkey, T: +90 332 2244496, ORCID: http://orcid.org/0000-0002-0287-5260.

Published: September 2018

Unlabelled: Levetiracetam (LEV) is a second-generation antiepileptic drug approved for the treatment of several types of epilepsy. We report a 45-year-old female who developed hypogammaglobulinemia and B cell aplasia during LEV treatment. The Naranjo probability score for an adverse drug reaction was 6. After LEV discontinuation, the number of B cells gradually increased and reached normal levels within two months. This case suggests that monitoring of immunoglobulin levels and lymphocyte subsets analysis is important in patients treated with LEV, especially in cases of prolonged infections.

Similar Cases Published: 1.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6074184PMC
http://dx.doi.org/10.5144/0256-4947.2018.09.01.1430DOI Listing

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