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Montréal Neurological Institute, McGill University, Montréal, Canada.

Due to its complexity and size, the optimal scale or level at which to describe the brain remains an open question in neuroscience. A new study published in PLOS Biology shows that simplifying complex brain recordings makes them more useful for studying brain function.

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There have been few recent innovations since the introduction of cardioplegia more than 50 years ago. Surprisingly, cardioplegia as one of the most essential steps in terms of heart muscle protection during a surgical procedure requiring cardiac arrest has never been really standardized. As a consequence, a considerable variety of cardioplegic solutions and applications have developed: cold versus warm, crystalloid versus blood cardioplegia, antegrade versus retrograde or both, as well as different time schedules for repeated administration.

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BAD2matrix: Phylogenomic matrix concatenation, indel coding, and more.

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Lewis B. and Dorothy Cullman Program for Molecular Systematics The New York Botanical Garden, Bronx New York USA.

Premise: Common steps in phylogenomic matrix production include biological sequence concatenation, morphological data concatenation, insertion/deletion (indel) coding, gene content (presence/absence) coding, removing uninformative characters for parsimony analysis, recording with reduced amino acid alphabets, and occupancy filtering. Existing software does not accomplish these tasks on a phylogenomic scale using a single program.

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