AI Article Synopsis
- Type I NKT cells are specialized immune cells that detect glycolipid antigens via CD1d, leading to quick immune responses.
- Their activation influences both innate and adaptive immunity, impacting responses to cancer, infections, and inflammatory diseases.
- The development and function of NKT cells are shaped by the thymus and gut microbiome, which suggests a need for a combined ecological and evolutionary understanding of their role in health and disease.
Article Abstract
Type I natural killer T (NKT) cells are innate-like T lymphocytes that recognize glycolipid antigens presented by the MHC class I-like protein CD1d. Agonistic activation of NKT cells leads to rapid pro-inflammatory and immune modulatory cytokine and chemokine responses. This property of NKT cells, in conjunction with their interactions with antigen-presenting cells, controls downstream innate and adaptive immune responses against cancers and infectious diseases, as well as in several inflammatory disorders. NKT cell properties are acquired during development in the thymus and by interactions with the host microbial consortium in the gut, the nature of which can be influenced by NKT cells. This latter property, together with the role of the host microbiota in cancer therapy, necessitates a new perspective. Hence, this review provides an initial approach to understanding NKT cells from an ecological evolutionary developmental biology (eco-evo-devo) perspective.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743650 | PMC |
| http://dx.doi.org/10.3389/fimmu.2017.01858 | DOI Listing |
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