AI Article Synopsis
- The study investigates the role of the central nervous system (CNS) in primary Sjögren syndrome (pSS) using functional magnetic resonance imaging (fMRI) and regional homogeneity (ReHo) analysis to identify brain activity differences between pSS patients and healthy controls.
- Increased ReHo values were found in certain brain areas of pSS patients, including the right cerebrum and left limbic lobe, indicating heightened activity, while other areas like the visual cortex showed decreased ReHo values, suggesting neuronal dysfunction.
- Overall, the findings point to abnormal brain activity in specific regions associated with visual processing and integration in pSS patients, which may help understand the neurobiological mechanisms underlying the condition
Article Abstract
Background The involvement of the central nervous system in primary Sjögren syndrome (pSS) remains controversial. Functional magnetic resonance imaging (fMRI) is a relatively new method that can be applied to investigate the heterogeneity of central nervous system (CNS) involvement in pSS patients through regional homogeneity (ReHo) analysis. Purpose To collect data from pSS patients and healthy controls, and use ReHo analysis to elucidate the neurobiological mechanism of CNS involvement in pSS. Material and Methods Fourteen clinically diagnosed pSS patients and 14 age- and gender-matched healthy controls underwent resting-state fMRI. The data were processed by ReHo analysis. The double sample t-test was used to compare ReHo data between groups. Results Compared to controls, pSS patients had significantly increased ReHo values in the right cerebrum, left limbic lobe, right middle temporal gyrus, and the inferior parietal lobe. However, ReHo values significantly decreased in the right lingual gyrus, left cuneiform lobe, left superior occipital gyrus, bilateral middle occipital gyrus, and the fronto-parietal junction area ( P < 0.01, clusters ≥ 50 voxels). Conclusion This study demonstrates the abnormal brain activity in the visual cortex and fronto-parietal junction area in pSS patients, suggesting pathological neuronal dysfunction in these regions.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/0284185117749993 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Carbon Fiber Reinforced Hybrid Polyaryl-Ether-Ether-Ketone (PEEK) Spinal Fixation System: Technical Features and Preliminary Clinical Trial.
Indian J Orthop
January 2025
Department of Orthopaedic Surgery, Hillel Yaffe M.C., 3100 Hadera, Israel.
Objective: To present the clinical result of spinal fixation system made entirely of Carbon-Fiber-Reinforced (CFR)-Hybrid Polyaryl-Ether-Ether-Ketone (PEEK).
Summary Of Background Data: Fusion surgery has been used to treat chronic low back pain caused by degenerative disk disease (DDD). The traditional pedicle screw system made of titanium, though biocompatible, can lead to complications, such as stress shielding and implant failure.
Introduction: Periorbital melanosis (POM) is a poorly defined condition that is becoming an increasing aesthetic concern. With its multifactorial origin, it necessitates a thorough assessment of targeted multimodal treatments. The psychological impact and underlying pathogenesis have been underexplored, as evidenced by the gap between the roughly 100 indexed articles and the 150 million search engine results on treatments for dark circles.
View Article and Find Full Text PDFFood Confusion Between Edible and Poisonous Plants: A 22-Year Retrospective of the Southeastern France Poison Control Center.
Toxins (Basel)
December 2024
Aix Marseille Univ, APHM, INSERM, IRD, SESSTIM, Hôpital Sainte Marguerite, Clinical Pharmacology and Poison Control Centre, 13274 Marseille, France.
Objective: In some regions of the globe, accidental food confusion regarding plants can cause severe poisoning events and deaths. The aim of this study was to report on those confusions from the Marseille Poison Control Centre's (PCC) experience from 2002 to 2023.
Results: Over 22 years, 2197 food confusion events were managed with 321 different species.
Quality of Life Evaluation Before and After Pulmonary Lobe Resection for Benign Diseases: A Comparative Study Among Patients with Tuberculosis, Bronchiectasis, and Benign Lung Nodules.
Diseases
November 2024
Center for Research and Innovation in Precision Medicine of Respiratory Diseases, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania.
Background: Pulmonary lobe resection is a common surgical intervention for various benign lung diseases, including tuberculosis (TB), bronchiectasis, and benign lung nodules. While immediate clinical outcomes are well documented, the impact on patients' quality of life (QoL) remains less explored. This study aims to evaluate QoL before and after pulmonary lobe resection over a 6-month period among patients with benign lung diseases.
View Article and Find Full Text PDFAssociation between behavioral problems and parental stress in children and adolescents with epilepsy.
Epilepsy Behav
December 2024
Department of Neurology, Krishna Institute of Medical Sciences, Secunderabad, India. Electronic address:
Objective: The current study evaluated the association between behavioral problems in children and adolescents with epilepsy and parental stress.
Methods: A prospective observational study of 314 consecutive parents of children and adolescents with epilepsy who attended the out-patient epilepsy clinic of a tertiary care hospital was done between June 2022 and September 2023. Self-reported Child Behaviour Check List (CBCL) was reported by parents; who also reported the parental stress scale (PSS).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!