Background: The association between interleukin-10 (IL-10) gene rs1800896 polymorphism and susceptibility to acute pancreatitis (AP) has been investigated in several studies, but with contradictory findings. Therefore, a comprehensive meta-analysis is needed to assess the strength of such association.
Methods: Literatures on PubMed, EMBASE, and CNKI were searched to identify relevant studies. The strength of association between IL-10 gene rs1800896 polymorphism and AP risk was assessed using pooled odds ratios and 95% confidence intervals.
Results: Totally 7 case-control studies involving 1527 cases and 1511 controls were identified. Analyses proved that IL-10 gene rs1800896 polymorphism was significantly associated with an increased risk of AP. Stratification analysis of ethnicity found such significant association only among Asians, but not Caucasians.
Conclusion: IL-10 gene rs1800896 polymorphism increases the risk of AP.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728818 | PMC |
| http://dx.doi.org/10.1097/MD.0000000000009006 | DOI Listing |
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