An on-line solid-phase extraction disc packed with a phytic acid induced 3D graphene-based foam for the sensitive HPLC-PDA determination of bisphenol A migration in disposable syringes.

In this study, an on-line SPE-disc filled with phytic acid induced 3D graphene-based foam (PAGF) has been applied to the determination of the migration of bisphenol A (BPA) in disposable syringes. The approach is of quick, easy, sensitive and environmentally-friendly. Experimental conditions were investigated and optimized including the character of enriched material and the amount of migrated BPA under different temperature, time and pH conditions. The experimental results reveal that the approach presents a wide linear range between the signal response and the concentration of BPA from 1 to 1000ngmL, as well as the detection limit of 0.03ngmL. The recoveries from 73% to 117% are achieved. BPA could be found and detected in disposable syringe samples with the migration amount from 1.47 to 82.69ngmL, which is lower than the permissible values of National Standard People's Republic of China, GB 9685-2008.