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CD4+ T helper 2 cell-macrophage crosstalk induces IL-24-mediated breast cancer suppression.
JCI Insight
January 2025
Center for Cancer Immunology and Cutaneous Biology Research Center, Department of Dermatology and Krantz Family Center for Cancer Research, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
CD4+ T cells contribute to antitumor immunity and are implicated in the efficacy of cancer immunotherapies. In particular, CD4+ T helper 2 (Th2) cells were recently found to block spontaneous breast carcinogenesis. However, the antitumor potential of Th2 cells in targeting established breast cancer remains uncertain.
View Article and Find Full Text PDFA case of treatment-resistant erosive pustular dermatosis of the scalp.
SAGE Open Med Case Rep
January 2025
Memorial University of Newfoundland, St. John's, NL, Canada.
Erosive pustular dermatosis is a rare and chronic inflammatory condition of the scalp which can be mistaken for cutaneous malignancy, precancerous lesions, dermatitis or pyoderma gangrenosum. The recurrent and resistant characteristics of erosive pustular dermatosis of the scalp pose a challenge to successful management and remission of the condition. The purpose of this case report is to provide management options and treatment recommendations for refractory cases of erosive pustular dermatosis of the scalp.
View Article and Find Full Text PDFType 2 immunity to the rescue: enhancing antitumor immunity for skin cancer prevention.
J Clin Invest
January 2025
Department of Dermatology, and.
Article Synopsis
- The incidence and mortality rates of cutaneous squamous cell carcinoma (cSCC) are increasing, highlighting the urgent need for better prevention methods.
- Topical treatments like calcipotriol and 5-fluorouracil (5-FU) can eliminate actinic keratosis (AK) lesions, but their exact mechanisms weren't clear until recent research.
- A study shows that type 2 immunity, specifically the interaction between thymic stromal lymphopoietin (TSLP) and Th2 cells, is crucial for eliminating premalignant cells and could be targeted for cSCC prevention.
T helper 2 cell-directed immunotherapy eliminates precancerous skin lesions.
J Clin Invest
January 2025
Center for Cancer Immunology and Cutaneous Biology Research Center, Krantz Family Center for Cancer Research and Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts, USA.
The continuous rise in skin cancer incidence highlights an imperative for improved skin cancer prevention. Topical calcipotriol-plus-5-fluorouracil (calcipotriol-plus-5-FU) immunotherapy effectively eliminates precancerous skin lesions and prevents squamous cell carcinoma (SCC) in patients. However, its mechanism of action remains unclear.
View Article and Find Full Text PDFPreparation and Evaluation of Complexed Ubiquinone (Coenzyme Q10) Antiaging Hyaluronic Acid-Vitamin C Serum for Skin Care.
J Cosmet Dermatol
January 2025
Queen's Medical Research Institute, Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Background: Coenzyme Q10 (CoQ10) is widely recognized for its powerful antioxidant properties, sparking considerable interest in its application within skincare treatments. However, its inherently poor water solubility has posed a major challenge in formulating effective skincare products.
Methods: This research aimed to develop and evaluate a water-soluble CoQ10 serum by forming a complex with hydroxypropyl β-cyclodextrin (HPβCD).
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