Analysis and evaluation of the antimicrobial and anticancer activities of the essential oil isolated from from Hamedan, Iran.

Nat Prod Res

c Bio-Refinery Group, Faculty of New Technologies Engineering , Shahid Beheshti University, Zirab Campus , Savadkooh , I.R. Iran.

Published: June 2019

In this study, biological properties of the essential oil isolated from seeds of () were evaluated. GC-MS analysis revealed Trans-Anethole (80.63%), L-Fenchone (11.57%), Estragole (3.67%) and Limonene (2.68%) were the major compounds of the essential oil. Antibacterial activity of the essential oil against nine Gram-positive and Gram-negative strains was studied using disc diffusion and micro-well dilution assays. Essential oil exhibited the antibacterial activity against three Gram-negative strains of , , and . The preliminary study on toxicity of seed oil was performed using Brine Shrimp lethality test (BSLT). Results indicated the high toxicity effect of essential oil (LC50 = 10 μg/mL). anticancer activity of seed oil was investigated against human breast cancer (MDA-Mb) and cervical epithelioid carcinoma (Hela) cell lines by MTT assay. Results showed the seed oil behave as a very potent anticancer agent with IC50 of lower than 10 μg/mL in both cases.

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http://dx.doi.org/10.1080/14786419.2017.1423310DOI Listing

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