Following a merger of the Departments of Pathology, Clinical Biochemistry, and part of Medical Microbiology, our faculty agreed to deliver a new, unique undergraduate program "Specialist in Pathobiology" at the University of Toronto, in order to teach current concepts of mechanisms of disease to students selected from the large undergraduate science population. The emphasis was on molecular and cellular aspects of pathogenesis and not on the clinical practice of laboratory medicine and pathology. Based on the then new Department of Laboratory Medicine and Pathobiology, we drew upon our large faculty and new recruits in both basic and clinical science to deliver a new curriculum that is unique and dynamic. We began admitting students in 2000, and we have now graduated our 15th class. In this study, we describe our philosophy and goals for the program, and report its success based on student outcomes and innovative course offerings.
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http://dx.doi.org/10.1177/2374289517747594 | DOI Listing |
Neurology
February 2025
Division of Clinical and Metabolic Genetics, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Ontario, Canada.
Pathogenic variants in cause congenital muscular dystrophy through hypoglycosylation of alpha-dystroglycan (OMIM #615350). The established phenotypic spectrum of GMPPB-related disorders includes recurrent rhabdomyolysis, limb-girdle muscular dystrophy, neuromuscular transmission abnormalities, and congenital muscular dystrophy with variable brain and eye anomalies. We report a 9-month-old male infant with congenital muscular dystrophy, infantile spasms, and compound heterozygous pathogenic variants (c.
View Article and Find Full Text PDFNeurology
February 2025
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Objectives: To analyze sex differences in outcomes in Tourette syndrome (TS) and Persistent Motor or Vocal tic disorders (PMVT) in the Tourette Association of America International Consortium for Genetics (TAAICG) dataset.
Methods: The relationship between sex and clinical measures was explored in 2,403 participants (N = 2,109 with TS; N = 294 with PMVT) from the TAAICG dataset using generalized estimating equation regression models, and adjusted for age and family relationships.
Results: Female (vs male) participants with TS (25.
Sci Transl Med
January 2025
Hypothalamic Research Center, Department of Internal Medicine, UT Southwestern Medical Center, Dallas TX, 75390, USA.
Disruption of hypothalamic melanocortin 4 receptors (MC4Rs) causes obesity in mice and humans. Here, we investigated the transcriptional regulation of in the hypothalamus. In mice, we show that the homeodomain transcription factor Orthopedia (OTP) is enriched in MC4R neurons in the paraventricular nucleus (PVN) of the hypothalamus and directly regulates transcription.
View Article and Find Full Text PDFEnviron Technol
January 2025
Department of Chemistry and Biology, Toronto Metropolitan University, Toronto, Canada.
Biosolids has several challenges, such as its high water content, huge volume, odour, and pathogen presence. Regulations require biosolids to be reused and disposed of safely. Polymer conditioning focuses on volume reduction, leaving pathogen and odour reduction unaddressed.
View Article and Find Full Text PDFJ Acquir Immune Defic Syndr
November 2024
Center for Interdisciplinary Research in Sexuality, AIDS and Society. Universidad Peruana Cayetano Heredia, Lima, Peru.
Background: Latin America-amidst its largest mass migration-has seen minimal progress in curbing new HIV infections. Transgender women (TW) in the region are disproportionately affected, but scant data examines HIV vulnerabilities alongside migration.
Methods: Between February-July 2022, 211 young TW ages 16-24 in Lima participated in a cross-sectional quantitative study accompanied by serological testing (HIV, syphilis, chlamydia, gonorrhea, hepatitis B).
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