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Pancytopenia after administration of intralesional methotrexate in a patient in hemodialysis program.
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May 2021
Unidad de Gestión Clínica de Hematología y Hemoterapia. Hospital Universitario Virgen de las Nieves, Granada, España. Electronic address:
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Equipo de Atención Primaria de Río de Janeiro, Barcelona, España.
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Article Synopsis
- Azathioprine is an immunosuppressive medication used effectively for treating inflammatory bowel disease, with its active metabolite being 6-mercaptopurine.
- Patients with low levels of the enzyme thiopurine methyltransferase may experience more severe side effects, including leukopenia and, in rare cases, pancytopenia.
- Monitoring thiopurine methyltransferase activity is important but should complement regular blood tests, especially in cases of fever and severe neutropenia, where early antibiotic treatment is critical to avoid infections.
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