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Liposomes-Loaded miR-9-5p Alleviated Hypoxia-Ischemia-Induced Mitochondrial Oxidative Stress by Targeting ZBTB20 to Inhibiting Nrf2/Keap1 Interaction in Neonatal Mice.
Antioxid Redox Signal
January 2025
Department of Physiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, People's Republic of China.
Hypoxia ischemia (HI) is a leading cause of cerebral palsy and long-term neurological sequelae in infants. Given that mitochondrial dysfunction in neurons contributes to HI brain damage, this study aimed to investigate the regulatory role of miR-9-5p in mitochondrial function following HI injury. Overexpression of miR-9-5p in HI mice or HO-exposed PC12 cells suppressed neuronal injury, associated with increased mitochondrial copy number, normalizing mitochondrial membrane potential, improved nuclear factor-erythroid factor 2-related factor 2 (Nrf2) activation, and downregulation of Keap1.
View Article and Find Full Text PDFApplication of Short Peptide Enteral Nutrition in Mechanically Ventilated Critically Ill Children with Severe Pneumonia and Its Impact on Patient Recovery.
Infect Drug Resist
January 2025
Science & Technology Innovation Center, Guangyuan Central Hospital, Guangyuan, People's Republic of China.
Objective: To explore the application of short-peptide enteral nutrition formulation in mechanically ventilated pediatric patients with severe pneumonia and its impact on rehabilitation outcomes, providing practical clinical evidence for the nutritional support strategy in critically ill pneumonia children.
Methods: This study retrospectively analyzed the clinical data of 90 neonatal pneumonia patients undergoing mechanical ventilation from May 2022 to December 2023. The patients were divided into an experimental group receiving short peptide enteral nutrition formulation via nasogastric tube and a control group receiving whole-protein enteral nutrition formulation via nasogastric tube.
A Scoping Review of Existing Policy Instruments to Tackle Overweight and Obesity in India: Recommendations for a Social and Behaviour Change Communication Strategy.
F1000Res
January 2025
Health Promotion Division, Public Health Foundation of India, New Delhi, Delhi, 110030, India.
Background: The Indian government is committed to addressing various manifestations of malnutrition, including overweight and obesity, inorder to improve individual health and well-being. The scoping review aims to map existing national policy instruments (programmes, schemes, regulations and guidelines) addressing overweight and obesity in India and analysing them for Social and Behaviour Change Communication (SBCC) strategies.
Methods: Systematic identification and selection of policy instruments using 'Arksey and O'Malley' framework was conducted from central government ministry websites, between March and June 2023.
The relationship between maternal vitamin D levels and osteopenia development in preterm infants: A cross-sectional study.
Int J Reprod Biomed
November 2024
Department of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Background: Osteopenia of prematurity (OP) is characterized by reduced bone mineral content, and vitamin D deficiency may worsen OP by affecting bone metabolism.
Objective: This study aimed to investigate the correlation between maternal vitamin D levels and biochemical markers related to OP.
Materials And Methods: This analytical cross-sectional study, conducted at Shahid Sadoughi hospital, Yazd, Iran, from June 2022 to September 2023, included 49 pregnant women and their preterm infants.
Complete shielding of multivitamins to reduce toxic peroxides in the parenteral nutrition (C-SMART-PN): A randomized controlled pilot study.
Nutr Clin Pract
January 2025
Department of Nutrition, Centre Hospitalier Universitaire Sainte-Justine Research Center, Université de Montréal, Montréal, Québec, Canada.
Background: When exposed to ambient light, parenteral nutrition (PN) contamination with peroxides almost doubles, which increases oxidative stress in preterm infants, contributing to the development of bronchopulmonary dysplasia. The American Society for Parenteral and Enteral Nutrition (ASPEN) recommends complete PN photoprotection to reduce peroxide contamination and optimize its integrity but acknowledges the challenges of its implementation. In this study, a novel photoprotection procedure was tested for its effectiveness in reducing peroxide load and limiting ascorbic acid degradation, and for its feasibility and effectiveness in reducing urinary peroxide levels in preterm infants.
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