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<PubmedArticle><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29304176</PMID><DateCompleted><Year>2018</Year><Month>01</Month><Day>29</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>13</Volume><Issue>1</Issue><PubDate><Year>2018</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS One</ISOAbbreviation></Journal><ArticleTitle>Prediction of delayed graft function and long-term graft survival by serum and urinary neutrophil gelatinase-associated lipocalin during the early postoperative phase after kidney transplantation.</ArticleTitle><Pagination><StartPage>e0189932</StartPage><MedlinePgn>e0189932</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">e0189932</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0189932</ELocationID><Abstract><AbstractText>Neutrophil gelatinase-associated lipocalin (NGAL) has emerged as an early marker protein for kidney dysfunction in various clinical settings. In this prospective study we evaluated serial changes of serum and urinary NGAL within the first 7 days after kidney transplantation in 170 consecutive recipients. The main focus of this study was to assess the performance of serum and urinary NGAL in the prediction of delayed graft function (DGF) and two-year graft and patient survival. Serum and urine samples of 170 patients undergoing primary kidney transplantation from October 2010 to December 2012 were prospectively collected from day 0 to 7. NGAL was analyzed by ELISA. Multivariate regression models, receiver-operating characteristics (ROC), and areas under ROC curves (AUC) were used to identify predictors of DGF. DGF occurred in 52 patients (30.6%). Serum (AUC = 0.869) and urinary NGAL (AUC = 0.872) on postoperative day (POD) 2 could accurately predict DGF compared to serum creatinine (AUC = 0.619). Multivariate analyses revealed donor age, serum and urinary NGAL significantly associated with DGF (p&lt;0.001). Recipient age was the only significant factor in a cox regression model influencing two-year graft and patient survival. In conclusion, serum and urinary NGAL are early predictors of DGF after kidney transplantation.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Maier</LastName><ForeName>Herbert Thomas</ForeName><Initials>HT</Initials><Identifier Source="ORCID">0000-0002-9455-4092</Identifier><AffiliationInfo><Affiliation>Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ashraf</LastName><ForeName>Muhammad Imtiaz</ForeName><Initials>MI</Initials><AffiliationInfo><Affiliation>Daniel-Swarovski-Research Laboratory, Innsbruck Medical University, Innsbruck, Austria.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Charit&#xe9; Universit&#xe4;tsmedizin Berlin, Department of Surgery, Campus Virchow-Klinikum and Campus Mitte, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Denecke</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Charit&#xe9; Universit&#xe4;tsmedizin Berlin, Department of Surgery, Campus Virchow-Klinikum and Campus Mitte, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weiss</LastName><ForeName>Sascha</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Charit&#xe9; Universit&#xe4;tsmedizin Berlin, Department of Surgery, Campus Virchow-Klinikum and Campus Mitte, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Augustin</LastName><ForeName>Florian</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Messner</LastName><ForeName>Franka</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vallant</LastName><ForeName>Natalie</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>B&#xf6;cklein</LastName><ForeName>Matthias</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Daniel-Swarovski-Research Laboratory, Innsbruck Medical University, Innsbruck, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Margreiter</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>G&#xf6;bel</LastName><ForeName>Georg</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Medical Statistics, Informatics and Health Economics, Innsbruck Medical University, Innsbruck, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pratschke</LastName><ForeName>Johann</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Charit&#xe9; Universit&#xe4;tsmedizin Berlin, Department of Surgery, Campus Virchow-Klinikum and Campus Mitte, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>&#xd6;fner-Velano</LastName><ForeName>Dietmar</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aigner</LastName><ForeName>Felix</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Charit&#xe9; Universit&#xe4;tsmedizin Berlin, Department of Surgery, Campus Virchow-Klinikum and Campus Mitte, Berlin, Germany.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>01</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C489506">LCN2 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000071068">Lipocalin-2</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051799" MajorTopicYN="Y">Delayed Graft Function</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004797" MajorTopicYN="N">Enzyme-Linked Immunosorbent Assay</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006085" MajorTopicYN="Y">Graft Survival</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016030" MajorTopicYN="Y">Kidney Transplantation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000071068" MajorTopicYN="N">Lipocalin-2</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000652" MajorTopicYN="Y">urine</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011184" MajorTopicYN="N">Postoperative Period</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016019" MajorTopicYN="N">Survival Analysis</DescriptorName></MeshHeading></MeshHeadingList><CoiStatement><b>Competing Interests: </b>The authors have declared that no competing interests exist.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>7</Month><Day>3</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>12</Month><Day>5</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>1</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>1</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>1</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pmc-release"><Year>2018</Year><Month>1</Month><Day>5</Day></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29304176</ArticleId><ArticleId IdType="pmc">PMC5755755</ArticleId><ArticleId IdType="doi">10.1371/journal.pone.0189932</ArticleId><ArticleId IdType="pii">PONE-D-17-25116</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Boros P and Bromberg JS. 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               <h2><a href="https://www.litmetric.com/detail/29304176/Prediction-of-delayed-graft-function-and-long-term-graft-survival-by-serum-and-urinary-neutrophil-ge" >Prediction of delayed graft function and long-term graft survival by serum and urinary neutrophil gelatinase-associated lipocalin during the early postoperative phase after kidney transplantation.</a></h2>
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                <div class="publication-auther"><a href="https://www.litmetric.com/author/Herbert+Thomas+Maier" class="tag" style="margin-bottom: 5px;">Herbert Thomas Maier</a> <a href="https://www.litmetric.com/author/Muhammad+Imtiaz+Ashraf" class="tag" style="margin-bottom: 5px;">Muhammad Imtiaz Ashraf</a> <a href="https://www.litmetric.com/author/Christian+Denecke" class="tag" style="margin-bottom: 5px;">Christian Denecke</a> <a href="https://www.litmetric.com/author/Sascha+Weiss" class="tag" style="margin-bottom: 5px;">Sascha Weiss</a> <a href="https://www.litmetric.com/author/Florian+Augustin" class="tag" style="margin-bottom: 5px;">Florian Augustin</a> <a href="https://www.litmetric.com/author/Franka+Messner" class="tag" style="margin-bottom: 5px;">Franka Messner</a> <a href="https://www.litmetric.com/author/Natalie+Vallant" class="tag" style="margin-bottom: 5px;">Natalie Vallant</a> <a href="https://www.litmetric.com/author/Matthias+Boecklein" class="tag" style="margin-bottom: 5px;">Matthias Böcklein</a> <a href="https://www.litmetric.com/author/Christian+Margreiter" class="tag" style="margin-bottom: 5px;">Christian Margreiter</a> <a href="https://www.litmetric.com/author/Georg+Goebel" class="tag" style="margin-bottom: 5px;">Georg Göbel</a> <a href="https://www.litmetric.com/author/Johann+Pratschke" class="tag" style="margin-bottom: 5px;">Johann Pratschke</a> <a href="https://www.litmetric.com/author/Dietmar+OEfner-Velano" class="tag" style="margin-bottom: 5px;">Dietmar Öfner-Velano</a> <a href="https://www.litmetric.com/author/Felix+Aigner" class="tag" style="margin-bottom: 5px;">Felix Aigner</a></div>                   
                    <p class="mb-0 dark-color fz15 fw500 list-inline-item ml15 mb5-sm ml0-xs"><i class="flaticon-contract vam fz20 me-2"></i> PLoS One</p>
              
                   <p class="mb-0 dark-color fz15 fw500 list-inline-item mr15  mb5-sm ml0-xs"><i class="flaticon-place text-thm2 vam fz20 me-2"></i> Department of Visceral, Transplant and Thoracic Surgery, <a href='https://www.litmetric.com/search/Innsbruck+Medical+University%5BAffiliation%5D' style='text-decoration: underline'>Innsbruck Medical University</a>, Innsbruck, Austria.</p>
                    
                     
                   <p class="mb-0 dark-color fz15 fw500 list-inline-item ml15 mb5-sm ml0-xs"><i class="flaticon-calendar vam fz20 me-2"></i> Published: January 2018</p>
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                   <p class="text mb30"><p class="text mt10">Neutrophil gelatinase-associated lipocalin (NGAL) has emerged as an early marker protein for kidney dysfunction in various clinical settings. In this prospective study we evaluated serial changes of serum and urinary NGAL within the first 7 days after kidney transplantation in 170 consecutive recipients. The main focus of this study was to assess the performance of serum and urinary NGAL in the prediction of delayed graft function (DGF) and two-year graft and patient survival. Serum and urine samples of 170 patients undergoing primary kidney transplantation from October 2010 to December 2012 were prospectively collected from day 0 to 7. NGAL was analyzed by ELISA. Multivariate regression models, receiver-operating characteristics (ROC), and areas under ROC curves (AUC) were used to identify predictors of DGF. DGF occurred in 52 patients (30.6%). Serum (AUC = 0.869) and urinary NGAL (AUC = 0.872) on postoperative day (POD) 2 could accurately predict DGF compared to serum creatinine (AUC = 0.619). Multivariate analyses revealed donor age, serum and urinary NGAL significantly associated with DGF (p<0.001). Recipient age was the only significant factor in a cox regression model influencing two-year graft and patient survival. In conclusion, serum and urinary NGAL are early predictors of DGF after kidney transplantation.</p><table class="table table-bordered table-striped downloadTable" >
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