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Formulation, Development, and Characterization of AMB-Based Subcutaneous Implants using PCL and PLGA via Hot-Melt Extrusion.
AAPS PharmSciTech
December 2024
Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, Mississippi, 38677, USA.
The hot-melt extrusion process is currently considered a prominent manufacturing technique in the pharmaceutical industry. The present study is intended to develop amlodipine besylate (AMB)-loaded subcutaneous implants to reduce the frequency of administration, thus improving patient compliance during hypertension management. AMB subcutaneous implants were prepared using continuous hot-melt extrusion technology using poly(caprolactone) and poly(lactic-co-glycolic acid) with dimensions of 3.
View Article and Find Full Text PDFQuadriceps muscle strength of the affected limb in medial meniscus posterior root tears is negatively correlated with the progression of postoperative medial joint space narrowing.
J Exp Orthop
October 2024
Department of Orthopaedic Surgery, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences Okayama University Okayama Japan.
Purpose: The effect of quadriceps muscle strength on medial joint space (MJS) narrowing after repair for medial meniscus (MM) posterior root tears (MMPRTs) has not yet been determined. This study aimed to evaluate the effect of preoperative and postoperative quadriceps muscle strength on the change in MJS (ΔMJS) in MMPRTs.
Methods: Thirty patients who underwent pullout repair for MMPRTs were retrospectively evaluated.
Delayed Screw Migration Following Anterior Cervical Discectomy and Fusion.
World Neurosurg
December 2024
Department of Neurosurgery, Icahn School of Medicine, New York, New York, USA. Electronic address:
Objective: To identify the clinical and surgical characteristics and treatment options of patients suffering delayed (>1 month) screw back-out after anterior cervical discectomy and fusion (ACDF).
Methods: A systematic review was performed searching Embase, Medline, and Scopus for relevant case studies and case series of delayed screw back-out after ACDF.
Results: A total of 25 studies encompassing 31 patients were identified and included.
Clinical Management of Orofacial Trauma Including Multiple Avulsions, Lateral Luxation, and Alveolar Fracture: A Case Report with 7-Years of Follow-Up.
J Endod
November 2024
Department of Dentistry, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil. Electronic address:
The occurrence of different types of trauma concomitantly can complicate the establishment of the most appropriate treatment. This report describes the clinical management of orofacial trauma including multiple avulsions, lateral luxation, alveolar fracture, and their sequelae after 7 years of follow-up. A 19-year-old woman presented to emergency care 4 hours after an accidental fall that resulted in the avulsion of teeth #8, #9, and #25; a complicated crown fracture and lateral luxation of tooth #7; an uncomplicated crown fracture of tooth #10; and a fracture of the maxillary alveolar bone.
View Article and Find Full Text PDFClinical effect of medial meniscus posterior root repair combined with centralization technique in the treatment of medial meniscus posterior root tears.
BMC Musculoskelet Disord
November 2024
Department of Joint Surgery, Affiliated Jinhua Hospital, Zhejiang University School of Medicine (Jinhua Municipal Central Hospital), Jinhua, 321000, China.
Purpose: To investigate the clinical effect of medial meniscus posterior root repair combined with centralization technique in treating medial meniscus posterior root tears (MMPRTs).
Methods: A retrospective analysis was conducted on 87 patients with MMPRTs treated in the Department of Joint Surgery of Jinhua Central Hospital from January 2020 to May 2022. Thirty-four patients were males and 53 were females, with an overall average age of 56.
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