We report the outcome of 27 children with de novo acute megakaryoblastic leukemia (AMKL) (excluding Down syndrome) enrolled in the French multicenter prospective study ELAM02 (2005-2011). There was no difference in gender, initial leukocyte count, CNS involvement, and complete remission rate (88.9%), as compared to other acute myeloid leukemia (AML) subtypes. AMKL patients had a significantly poorer outcome (5-year overall survival 54% [CI 95% 33%-71%] than children with other AML subtypes (5-year overall survival 73% [CI 95% 68%-77%] p = 0.02). Gender, age, CNS leukemia, hyperleukocytosis, complete remission or cytogenetic subgroups were not significant prognostic factors of disease-free survival. AMKL (excluding Down syndrom) remains an AML subgroup with inferior outcome.
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| http://dx.doi.org/10.1080/08880018.2017.1414905 | DOI Listing |
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Article Synopsis
- Transient abnormal myelopoiesis (TAM) in neonates with Down syndrome (DS) presents similarly to acute megakaryoblastic leukemia but usually resolves on its own within months postpartum.
- Some cases of TAM can lead to severe health issues, impacting the patient's prognosis negatively.
- An autopsy of a stillborn female with TAM and DS revealed GATA1s protein expression in unusual immature megakaryocytes, indicating that placental tissue can be useful for diagnosing TAM histologically.
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