A novel palladium-catalyzed intermolecular ditrifluoromethoxylation of unactivated alkenes has been developed, using a new electrophilic reagent, Selectfluor, as a strong oxidant, and AgOCF as a trifluoromethoxide source. Preliminary mechanistic studies revealed that the reaction was possibly initiated by Pd(IV) species, and an unusual cis-addition of CFO-Pd(IV) into the double bond leads to the formation of the first C-OCF bond; in addition, the second C-OCF bond was produced through reductive elimination at high-valent palladium center.
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| http://dx.doi.org/10.1021/jacs.7b11470 | DOI Listing |
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