Ciguatera Fish Poisoning (CFP) is a human illness caused by the consumption of marine fish contaminated with ciguatoxins (CTX) and possibly maitotoxins (MTX), produced by species from the benthic dinoflagellate genus . Here, we describe the identity and toxicology of spp. isolated from the tropical and temperate waters of eastern Australia. Based on newly cultured strains, we found that four species were present at the tropical location, including , and two others which were not genetically identical to other currently described species within the genus, and may represent new species. Only was identified from the temperate location. Using LC-MS/MS analysis we did not find any characterized microalgal CTXs (P-CTX-3B, P-CTX-3C, P-CTX-4A and P-CTX-4B) or MTX-1; however, putative maitotoxin-3 (MTX-3) was detected in all species except for the temperate population of Using the Ca influx SH-SY5Y cell Fluorescent Imaging Plate Reader (FLIPR) bioassay we found CTX-like activity in extracts of the unidentified strains and trace level activity in strains of While no detectable CTX-like activity was observed in tropical or temperate strains of , all species showed strong maitotoxin-like activity. This study, which represents the most comprehensive analyses of the toxicology of strains isolated from Australia to date, suggests that CFP in this region may be caused by currently undescribed ciguatoxins and maitotoxins.
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| http://dx.doi.org/10.3390/md16010007 | DOI Listing |
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