Summary: Size-exclusion chromatography (SEC) coupled to small-angle X-ray scattering (SAXS), also known as inline SEC-SAXS, is being increasingly used for the structural analysis of biological macromolecules, complexes and mixtures in solution. A single SEC-SAXS run generates thousands of individual SAXS profiles from the eluting solute and their analysis requires a correct identification of buffer and sample regions, a rather laborous task. We present CHROMIXS (as in CHROMatography Inline X-ray Scattering), a program for rapid reduction and analysis, both automatically and interactively, of SEC-SAXS data.
Availability And Implementation: CHROMIXS is freely available to academic users as part of the ATSAS software suite (www.embl-hamburg.de/biosaxs/download.html).
Contact: apanjkovich@embl-hamburg.de or svergun@embl-hamburg.de.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972624 | PMC |
| http://dx.doi.org/10.1093/bioinformatics/btx846 | DOI Listing |
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