AI Article Synopsis
- A new set of Ru(ii) metallopeptides with the dppz ligand was created using Solid Phase Peptide Synthesis (SPPS) techniques.
- The presence of an octaarginine tail significantly enhances the binding affinity of these metallopeptides to DNA G-quadruplex structures compared to those without the tail, highlighting the importance of both the tail and ancillary ligand in the recognition process.
- These oligoarginine metallopeptides are effectively taken up by cells and lead to cell death, exhibiting characteristics of apoptosis.
Article Abstract
A set of Ru(ii) metallopeptides containing the dppz ligand has been synthesized using SPPS methods. Fluorescence titration studies show that those metallopeptides featuring an octaarginine tail display a large binding preference for DNA G-quadruplex structures over those lacking it, and also that the interplay between the octoarginine functionalization and the ancillary ligand in the complex has an essential role in the recognition process. Furthermore, the oligoarginine metallopeptides are also efficiently internalized, causing cell death with signs of apoptosis.
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| http://dx.doi.org/10.1039/c7cc08286j | DOI Listing |
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