AI Article Synopsis
- An 8 mg/kg dose of Cefovecin (Convenia®) was given intramuscularly to eight anesthetized tigers to study its pharmacokinetics through blood sampling over 56 days.
- The study found that Cefovecin had a mean terminal half-life of about 227.8 hours and remained above therapeutic levels (>1 μg/ml) for the entire 56-day period.
- Cefovecin showed a high protein binding rate of 98% in tiger plasma, highlighting its effectiveness as a long-lasting antimicrobial treatment without adverse effects.
Article Abstract
A single 8 mg/kg dose of Cefovecin (Convenia®) was administered intramuscularly in the hindlimb of eight anesthetized captive tigers ( Panthera tigris) and serial blood samples were collected over the next 56 days to determine pharmacokinetic characteristics. High-performance liquid chromatography was utilized to determine plasma levels, and demonstrated a mean terminal half-life of 227.8 ± 29.3 hr. Cefovecin, >1 μg/ml, was detected in plasma levels up to 56 days postinjection. Protein binding of tiger plasma for cefovecin was 98%. The long duration of therapeutic plasma concentrations and lack of adverse effects make cefovecin a useful antimicrobial drug for tigers.
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| http://dx.doi.org/10.1638/2017-0083.1 | DOI Listing |
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