Single-agent vemurafenib leads to a rapid and sustained clinical response in severe multisystem LCH but does not eradicate the disease.Longitudinal assessment of V600E during treatment shows that clinical remission can occur despite significant amounts of mutated BRAF.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738993 | PMC |
| http://dx.doi.org/10.1182/bloodadvances.2016003533 | DOI Listing |
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