Background: Gastrointestinal (GI) symptoms are common in the general population. This investigation studied the effects of (CF), a natural product, on GI motility.
Methods: We checked the intestinal transit rates (ITRs) or gastric emptying in normal and in GI-motility-dysfunction (GMD) mice . The GMD mice were made by acetic acid or streptozotocin.
Results: Both ITRs and gastric emptying were increased by CF (0.0025-0.25 g/kg) dose dependently. Also, in the GMD mice models, acetic-acid-induced peritoneal irritation, and streptozotocin-induced diabetic mice, the ITRs were decreased compared to normal mice, and these decreases were inhibited by CF.
Conclusion: These results suggest that CF is one of the good candidates for the development of a prokinetic agent that may regulate GI-motility functions.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741384 | PMC |
| http://dx.doi.org/10.1016/j.imr.2017.08.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!