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[Clinical, biochemical and epidemiological features of macro-AST preceding inflammatory bowel disease diagnosis by several years].
Rev Med Interne
May 2023
Service de biochimie, hôpital européen Georges-Pompidou, assistance publique-hôpitaux de Paris (AP-HP), 75013 Paris, France.
Introduction: An isolated elevation of aspartate aminotransferase (AST) is a diagnostic issue. Macro-aspartate aminotransferase (macro-AST) corresponds to the formation of complexes between AST and immunoglobulins.
Case Report: We report the case of a patient with macro-AST identified several years before the onset of inflammatory bowel disease (IBD).
Macro-Aspartate Aminotransferase and Its Laboratory Detection: A Case Report.
Acta Med Litu
July 2023
Center of Laboratory Medicine, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.
Background: Increased enzyme activity in human blood serum is usually associated with the existence of disease. On the other hand, enzyme activity can also be elevated in the presence of benign conditions, such as macro-enzymes. Macro-enzymes could lead to highly unnecessary and invasive procedures which may cause complications to the patient and an extra cost for the hospital.
View Article and Find Full Text PDFMacro-Aspartate Aminotransferase: A Benign Cause of Abnormal Laboratory Findings.
Cureus
April 2022
Gastroenterology, Dayton Veterans Affairs Medical Center, Wright State University, Dayton, USA.
Article Synopsis
- Isolated and persistent increases in aspartate aminotransferase (AST) can create diagnostic challenges due to a lack of clear explanations.
- Macro-enzyme aspartate aminotransferase (macro-AST) is a rare and harmless cause for these elevated AST levels when no other illnesses are present.
- A case study is presented involving a healthy adult male with macro-AST, which was confirmed through a polyethylene glycol (PEG) precipitation test.
A Case of Macroenzyme Aspartate Aminotransferase Mimicking Hepatic Injury.
Cureus
August 2021
Department of Gastroenterology, Carilion Clinic, Roanoke, USA.
Macroenzymes are high molecular weight complexes that are formed by the binding of normal serum enzymes with circulating immunoglobulins - primarily IgG, IgA, and IgM. These high molecular weight complexes are difficult to clear through the kidneys, therefore they remain persistently elevated in the serum leading to inaccurate diagnoses and unnecessary workup. The prevalence of macroenzymes is relatively rare in the general population; however, it is an important phenomenon to be aware of when working up isolated elevations in serum enzymes.
View Article and Find Full Text PDFMacro-aspartate aminotransferase in a healthy woman.
Clin Mol Hepatol
July 2020
Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
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