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Filename: controllers/Detail.php
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Radiation therapy allows precision targeting of certain groups of lymph nodes and is a treatment for metastatic head and neck squamous cell carcinoma. In current practice, there is approximately 15% probability that physicians inadvertently treat healthy tissue or leave the cancerous lymph nodes untreated. The aim of this work is to improve the accuracy of medical decision-making by extending existing predictive models to capture the probabilities of finding cancerous lymph nodes at each of the six image-based surgical neck level using a patient's genetic profile, primary tumor site and tumor size. Our model was trained with publicly available data extracted from the Cancer Genome Atlas (TCGA) and validated against the TCGA dataset both with and without genetic information. Results show that genetic profile data improves model accuracy. These findings suggest that our predictive model may improve the accuracy of clinical decision-making, especially for patients with more advanced metastasis. However, more data is needed to ensure significance of the proposed effects, as well as to improve accuracy of the overall model.
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Front Vet Sci
December 2024
School of Veterinary Medicine and Biomedical Sciences, Department of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, United States.
Introduction: The objective of this study is to estimate reference values for medial retropharyngeal lymph nodes (MRLNs) measured in high-field (3T) MRI studies of the canine head/brain using transverse T2 spin-echo images and to determine if dogs with structural brain disease exhibit medial retropharyngeal lymph nodes that are larger than expected from estimated reference values.
Methods: The study population comprises 142 MRLNs from 71 dogs with no evidence of structural brain disease and normal CSF evaluation and 116 MRLNs from 58 dogs with structural brain disease confirmed by histopathology as of infectious or neoplastic origin, or to represent meningoencephalitis of unknown etiology.
Results: Based on this sample, MRLNs are expected to measure 2.
Front Surg
December 2024
Department of Thoracic Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Objective: Lung cancer is the leading cause of cancer-related mortality. Lymph node involvement remains a crucial prognostic factor in non-small cell lung cancer (NSCLC), and the TNM system is the current standard for staging. However, it mainly considers the anatomical location of lymph nodes, neglecting the significance of node count.
View Article and Find Full Text PDFInfect Drug Resist
December 2024
Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Purpose: Periprosthetic joint infection (PJI) is a severe complication following joint replacement surgery, and there is a current lack of rapid, accurate, and non-invasive diagnostic methods. This study aims to assess the effectiveness of using dual-energy computed tomography (DECT) to quantify the maximum long and short axes of the external iliac lymph nodes (LNs) as a diagnostic tool for PJI.
Patients And Methods: In this prospective controlled study, 112 patients undergoing total hip or total knee revision surgery were enrolled.
Adv Sci (Weinh)
December 2024
Department of Pharmaceutics, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China.
Paclitaxel (PTX) is a first-line chemotherapeutic drug for non-small cell lung cancer (NSCLC) but it can induce indoleamine 2,3-dioxygenase (IDO) activation, which severely lowers down its immuno-chemotherapeutic effect. To address this issue, a smart peptide hydrogelator Nap-Phe-Phe-Phe-Lys-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-OH (Nap-T), which co-assembles with PTX and an IDO inhibitor GDC0919 to form a hydrogel GP@Gel Nap-T, is rationally designed. Upon specific phosphorylation by pyruvate kinase M2 (PKM2), an overexpressed biomarker of NSCLC, Nap-T is gradually converted to Nap-Phe-Phe-Phe-Lys-Ser-Thr(HPO)-Gly-Gly-Lys-Ala-Pro-Arg-OH (Nap-Tp), leading to dehydrogelation and sustained release of PTX and GDC0919 within NSCLC tissues.
View Article and Find Full Text PDFJ Control Release
December 2024
Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Centre for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, People's Republic of China. Electronic address:
Self-adjuvanted vaccine delivery platforms possess potential for targeted delivery of antigens and initiation of potent immune responses. Although aluminum-containing adjuvants have been approved and widely used in human vaccines, their effectiveness in inducing Th1-type immune responses is far from satisfactory. To facilitate antigen delivery and activate potent antitumor immune responses, a self-adjuvanted nanovaccine (CPBG-Al@OVA) is constructed by functionalizing aluminum hydroxide with β-1,3-glucan, which recognizes pattern recognition receptors via Dectin-1.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!