AI Article Synopsis
- Approximately 1% of babies are born with congenital heart defects (CHDs), but advancements in surgery have significantly improved survival rates into adulthood.
- Ongoing monitoring is crucial for patients to track heart failure progression and decide when surgical interventions are needed; accurate quantification of heart shape and function plays a key role in this process.
- Recent developments include a computational atlas that helps measure changes in heart structure, using z scores for comparison across populations, which aids in understanding and analyzing heart conditions.
Article Abstract
Approximately 1% of all babies are born with some form of congenital heart defect. Many serious forms of CHD can now be surgically corrected after birth, which has led to improved survival into adulthood. However, many patients require serial monitoring to evaluate progression of heart failure and determine timing of interventions. Accurate multidimensional quantification of regional heart shape and function is required for characterizing these patients. A computational atlas of single ventricle and biventricular heart shape and function enables quantification of remodeling in terms of z scores in relation to specific reference populations. Progression of disease can then be monitored effectively by longitudinal evaluation of z scores. A biomechanical analysis of cardiac function in relation to population variation enables investigation of the underlying mechanisms for developing pathology. Here, we summarize recent progress in this field, with examples in single ventricle and biventricular congenital pathologies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910190 | PMC |
| http://dx.doi.org/10.1007/s12265-017-9778-5 | DOI Listing |
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