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Background: Delayed cerebral ischemia (DCI) is a major cause of disability after aneurysmal subarachnoid hemorrhage (aSAH). Activated platelets are surrogate markers for DCI occurrence and are reliably represented by mean platelet volume (MPV) to platelet count (PLT) ratio. If validated as a predictor of DCI, the ratio will allow clinicians to use it as a readily available tool in patient management.
Methods: Retrospective analysis of aSAH patient database at a tertiary care hospital. MPV:PLT ratio was defined as (MPV value(fL)PLT per 1000∗100). Nonlinear regression estimated differences in the ratio's pattern of change over time between those with or without DCI. Receiver operating characteristic curve determined optimal threshold of rise in MPV:PLT ratio to predict DCI.
Results: Average age of the cohort (n = 169) was 53.0 ± 13.0 years, and 38 patients (22.5%) developed DCI. Nonlinear regression analysis detected a transition of rising and declining MPV:PLT ratio at 3 days after aSAH. Rate of rise in MPV:PLT ratio was 0.5 units/day (95% confidence interval 0.3-0.7) in patients developing DCI as compared with 0.2 units/day (95% confidence interval 0.1-0.3) in those without DCI (P = 0.0004). Receiver operating characteristic analysis determined a threshold of 0.33 units/day rise in MPV:PLT predicted DCI with 89.5% sensitivity and 90.8% specificity. Patients who died demonstrated a steeper rise during the first 3 days (0.29 units/day) than those who were discharged home (0.21 units/day) (P = 0.004).
Conclusions: Trend of MPV:PLT ratio after aSAH predicts DCI. This association alludes to significant early rise in reactive platelet population after aSAH in patients developing DCI.
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http://dx.doi.org/10.1016/j.wneu.2017.12.131 | DOI Listing |
BMJ Open Ophthalmol
December 2024
Diabetes Research Center, Mazandaran University of Medical Sciences, Sari , Iran.
Objective: This prospective case-control study examined the novel immunoinflammatory markers obtained from blood counts of patients with Graves' orbitopathy (GO), Graves' disease (GD) and healthy subjects.
Methods: Demographic data, white cell count parameters, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), mean platelet volume (MPV), platelet-to-neutrophil ratio (PNR), red cell distribution width (RDW), RDW-to-platelet ratio (RDW/PLT), MPV-to-lymphocyte ratio (MPV/ALC), eosinophil-to-lymphocyte ratio (ELR) and systemic immune-inflammatory index (SII) were evaluated. The European Group on Graves Orbitopathy scale and Clinical Activity Score were used for clinical activity and severity assessment.
Vet Sci
November 2024
Department of Veterinary Sciences, School of Agricultural and Veterinary Sciences (ECAV), University of Trás-os-Montes e Alto Douro (UTAD), Quinta de Prados, 5000-801 Vila Real, Portugal.
This is a retrospective study about haematological ratios in different stages of canine periodontal disease in one single breed, more specifically the Portuguese Podengo. The aim of the study was to assess the clinical significance of five haematological ratios, namely neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), mean platelet volume-to-platelet count ratio (MPV/PLT), monocyte-to-lymphocyte ratio (MLR), and platelet-to-neutrophil ratio (PNR), easily obtained through the parameters provided by the complete blood count, in the stages of gingivitis and periodontitis, compared to clinical healthy individuals. Receiver operating characteristic curves were generated to identify ideal sensitivity and specificity cut-offs for cases of gingivitis or periodontitis.
View Article and Find Full Text PDFBMC Psychiatry
October 2024
Department for Bipolar Disorders, Clinic for Psychiatry, University Clinical Centre of Serbia, Pasterova 2, Belgrade, 11000, Serbia.
Background: Although repeatedly confirmed, the molecular nature of gene-environment (GxE) interactions has rarely been investigated in the clinical context of mood disorders. This study assesses the relationship between HTR2A genetic variants and the modulatory effect of inflammation in a collective cohort of patients with major depressive disorder (MDD) and bipolar disorder (BD), as a unified group with two distinct phenotypes.
Methods: The study included 138 patients with acute mood episodes (BD = 83; MDD = 55).
Objective: Exploration of the Predictive Diagnostic Value of Mean Platelet Volume to Platelet Count Ratio (MPV/PLT,PVI) and Neutrophil-to-Lymphocyte Ratio (NLR) in the tPSA Gray Zone of Prostate Cancer.
Methods: A retrospective study was conducted on 65 prostate cancer (Pca) patients and 52 benign prostatic hyperplasia (BPH) patients who underwent transperineal prostate biopsy at Xiangtan Central Hospital from December 2021 to December 2023. Descriptive statistics and logistic regression models were used to investigate the predictive diagnostic value of PVI and NLR in the tPSA gray zone of prostate cancer.
Sci Rep
October 2024
Département d'Anesthésie et Réanimation, Hopital Neurologique Pierre Wertheimer, Hospices Civils de Lyon (Lyon University Hospital), 59 Boulevard Pinel Bron, Lyon, 69500, France.
The morbidity of aneurysmal subarachnoid hemorrhage (aSAH) remains high, particularly because of secondary cerebral lesions that significantly aggravate the primary lesions. The main type of secondary lesions is delayed cerebral ischemia (DCI), in which platelets (PLT) appear to play a key role. Mean platelet volume (MPV) is an indirect marker of platelet activation.
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