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Psychiatrist Consultant, Department of Psychiatry, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.

Pain management is the hallmark of palliative care; however, pain is commonly underassessed in cases of advanced dementia and delirium (acute confusional state). We present a case of a 66-year-old female patient with severe dementia who was hospitalized because of behavioral changes and sleep disturbance. Symptoms of confusion, disorientation, inattention, and agitation were most severe at night.

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November 2024

Clinical Gerontology Department, CHU of Nantes, Nantes, France.

Article Synopsis
  • * It functions like "acute brain failure," often triggered by other health problems like infections or metabolic issues, and can have serious impacts on patients and the healthcare system.
  • * The review focuses on diagnosing delirium in older adults, discussing available screening tools, exploring its relationship with dementia, and outlining both non-drug and drug management strategies for treatment.
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Background: Delirium or an acute confusional state (ACS) is characterised as being a frequent and complex hospital complication in older adult patients, which can affect their level of independence and increase patient morbidity and mortality. Critically ill patients in the intensive care unit (ICU) frequently develop ICU delirium, leading to longer hospital and ICU stays, increased mortality and long-term impairment.

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Hyperammoniemic encephalopathy is part of the differential -diagnosis in the presence of an acute confusional state. Although associated with liver dysfunction in the majority of cases, it can be observed in many other clinical situations. Often not investigated, the dosage of ammonium in the blood should be integrated in the biological work-up of encephalopathy of unknown origin.

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