AI Article Synopsis
- Researchers developed multifunctional nanotheranostic nanoparticles (FeO-MTX@HBc) for better cancer imaging and treatment.
- These nanoparticles use engineered virus-like particles to encapsulate magnetic nanoparticles, enhancing their effectiveness and cellular uptake while avoiding detection by the immune system.
- The system shows improved photothermal efficiency with NIR laser irradiation and serves as a reliable MRI contrast agent, indicating its potential for multimodal cancer therapy.
Article Abstract
To accomplish effective cancer imaging and integrated therapy, the multifunctional nanotheranostic FeO-MTX@HBc core-shell nanoparticles (NPs) were designed. A straightforward method was demonstrated for efficient encapsulation of magnetic NPs into the engineered virus-like particles (VLPs) through the affinity of histidine tags for the methotrexate (MTX)-Ni chelate. HBc-His VLPs shell could protect FeO-MTX NPs from the recognition by the reticuloendothelial system as well as could increase their cellular uptake efficiency. Through our well-designed tactic, the photothermal efficiency of FeO NPs were obviously improved and upon near-infrared (NIR) laser irradiation. Moreover, Magnetic resonance imaging (MRI) results showed that the FeO-MTX@HBc core-shell NPs were reliable T-type MRI contrast agents for tumor imaging. Hence the FeO-MTX@HBc core-shell NPs may act as a promising theranostic platform for multimodal cancer treatment.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743840 | PMC |
| http://dx.doi.org/10.7150/ntno.21942 | DOI Listing |
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