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[Hodgkin lymphoma: Current and future therapeutic strategies]. | LitMetric

AI Article Synopsis

  • Hodgkin lymphoma (HL) primarily affects young individuals and has a high cure rate of over 80% with modern chemotherapy and radiotherapy, but survivors may face serious long-term health issues.
  • Current treatment strategies for HL are guided by initial risk assessments and have evolved from large clinical trials, though chemotherapy followed by radiation remains the standard for many localized cases.
  • Emerging treatments, like immune checkpoint inhibitors (particularly anti-PD1 antibodies), show promise in treating relapsed or refractory HL with fewer side effects, potentially reducing overall treatment toxicity in the future.

Article Abstract

Hodgkin lymphoma (HL) is a cancer that mostly affects young people, in which modern therapeutic strategies using chemotherapy and radiotherapy result in a cure rate exceeding 80%. Survivors are exposed to long-term consequences of treatments, such as secondary malignancies and cardiovascular diseases, whose mortality exceeds the one of the disease itself, with long-term follow-up. The current therapeutic strategy in HL, based on the assessment of initial risk factors, is the result of large clinical trials led by the main international cooperating groups. More recently, several groups have tried to develop treatment strategies adapted to the response to chemotherapy, evaluated by interim PET/CT scan. However to date, the combined treatment with chemotherapy followed by radiation therapy remains a standard in most of the above-diaphragmatic localized forms. Immune checkpoint inhibitors, and especially anti-PD1 antibodies, have shown dramatic results in some serious forms of relapsed or refractory HL, with limited toxicity, and may contribute in the future to reduce the toxicities of treatments.

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Source
http://dx.doi.org/10.1016/j.bulcan.2017.11.008DOI Listing

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