The aim of the present study was to investigate the association between cyclin-dependent kinase inhibitor 2A () and cyclin-dependent kinase inhibitor 2B () methylation, and coronary heart disease (CHD), and to explore the interaction between methylation status and CHD clinical characteristics in Han Chinese patients. A total of 189 CHD (96 males, 93 females) and 190 well-matched non-CHD controls (96 males, 94 females) were recruited for the study. Methylation-specific polymerase chain reaction technology was used to examine gene promoter methylation status. Comparisons of methylation frequencies between CHD and non-CHD patients were carried out using the Chi-square test. Methylation levels of and genes were not found to be associated with the risk of CHD. However, the mean age of -hypermethylated participants was significantly lower than -unmethylated participants (58.73±5.88 vs. 62.62±5.36 years, adjusted P<0.001). Conversely, the mean age of -hypermethylated participants was significantly higher compared with -unmethylated participants (62.26±5.48 vs. 58.33±7.47 years, adjusted P=0.048). In addition, methylation frequencies were significantly increased in female participants compared with males (99.47 vs. 11.98%, P=0.032). In conclusion, the results indicated that and promoter methylation frequencies were significantly associated with age, and there was a gender dimorphism in methylation.
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| http://dx.doi.org/10.3892/etm.2017.5310 | DOI Listing |
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