Background: Magnesium sulfate has been implicated to influence the minimum alveolar concentration (MAC) of various volatile anesthetics, but its effect on desflurane remains unanswered so far.
Aim: To study the effect of perioperative intravenous magnesium sulfate on MAC of desflurane using bispectral index (BIS) monitoring.
Settings: Operating room of a tertiary care hospital.
Design: A prospective, randomized, controlled, double-blind clinical trial.
Methods: Sixty American Society of Anesthesiologists Physical Status I/II patients aged 18-65 years and scheduled for breast conservative surgeries were randomized into three groups of 20 each. Control group (Group 1) was administered 100 ml normal saline (NS) as bolus followed by NS infusion. Magnesium (Mg) was administered as bolus of 40 mg/kg in 100 ml NS followed by NS infusion in Group 2 and as bolus of 40 mg/kg followed by infusion of 10 mg/kg/h of Mg in NS in Group 3. Anesthesia was induced with propofol, fentanyl, and atracurium. Dial setting of desflurane was adjusted to target a BIS of 45-55. Time from cessation of desflurane to beginning of spontaneous movement, time taken to respond to verbal commands, time of extubation, and time taken to reach BIS value of 70 were recorded.
Statistical Analysis: Statistics was done using SPSS program using ANOVA and the Chi-square test for variables and a < 0.05 was taken to indicate a significant difference.
Results: No significant difference was present in MAC, end-tidal desflurane, and cumulative consumption of morphine. Recovery was similar in Group 2 and Group 3, but time to eye opening ( = 0.011), time to respond to verbal commands ( < 0.001), and time to extubate ( < 0.001) were significantly delayed when compared with patients in Group 1. Hemodynamic changes were comparable among three groups.
Conclusions: From this study, we conclude that MACs of desflurane using BIS as a guide remains unaffected by perioperative infusion of magnesium sulfate.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735439 | PMC |
| http://dx.doi.org/10.4103/aer.AER_123_17 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mathematical modelling approach to understanding the effect of Mg-rich synthetic gypsum used as fertilizer on growth of Hevea brasiliensis in acid soils.
PLoS One
January 2025
School of Applied Sciences, University of West of England, Bristol, United Kingdom.
Knowledge of plant growth dynamics is essential where constraints such as COVID-19 lockdown restrictions have limited its field establishment. Thus, modeling can be used to predict plant performance where field planting/monitoring cannot be achieved. This study was conducted on the growth dynamics of rubber planted on two acid soils treated with either dolomitic limestone (GML), kieserite or Mg-rich synthetic gypsum (MRSG) to supply the Mg required by rubber seedlings.
View Article and Find Full Text PDFParameter Optimization and Precision Control of Water-Soluble Support Cores for Hollow Composite Castings Fabricated by Slurry Microextrusion Direct Forming Method.
3D Print Addit Manuf
October 2024
State Key Laboratory of Materials Processing and Die and Mould Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan, China.
The optimization of slurry content and forming process parameters has a significant effect in slurry microextrusion direct forming method. In this article, magnesium sulfate monohydrate (MgSO) and polyvinylpyrrolidone (PVP) were used as raw materials to prepare the slurry, and the component ratios of the slurry and the optimization of its forming process were discussed. The optimum slurry content is 64 wt.
View Article and Find Full Text PDFSurvival after aluminum phosphide poisoning with cardiotoxicity: a case report.
J Med Case Rep
December 2024
Department of Internal Medicine, Woldia Comprehensive Specialized Hospital, Woldia, Ethiopia.
Introduction: Aluminum phosphide is a cheap and commonly used rodenticide that is also an effective solid fumigant and frequently used for grain preservation. The pill contains around 44% inert elements (ammonium carbonate) to avoid disintegration of the tablet, while the rest (about 56%) is aluminum phosphide. Because it is freely available on the market, it is one of the commonly used agents for self-poisoning in different parts of the developing world.
View Article and Find Full Text PDFEffective multicolor visual biosensor for ochratoxin A detection enabled by DNAzyme catalysis and gold nanorod etching.
Mikrochim Acta
December 2024
Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, People's Republic of China.
A novel detection technique is introduced that offers sensitive and reliable ochratoxin A (OTA) detection. The method leverages the etching of gold nanorods (AuNRs) stabilized by hexadecyl trimethyl ammonium bromide (CTAB) using the oxidized form of 3,3',5,5'-tetramethyl benzidine sulfate (TMB), creating a susceptible multicolor visual detection system for OTA. The visual detection is enabled by Mg-assisted DNAzyme catalysis combined with the catalytic hairpin assembly (CHA) signal amplification strategy.
View Article and Find Full Text PDFMagnesium sulfate for fetal neuroprotection in preterm labor: an updated systematic review and meta-analysis of randomized controlled trials.
Arch Gynecol Obstet
December 2024
Unit of Obstetrics and Gynecology, "Paolo Giaccone" Hospital, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127, Palermo, Italy.
Objective: Antenatal magnesium sulfate has been reported to reduce the risk of neurological impairment in fetuses born to women at risk of preterm labor. However, the evidence to support its use is conflicting. We conducted this meta-analysis to assess the efficacy and safety of magnesium sulfate in women at risk of preterm labor as new research is available from RCTs giving insights into MgSO4 treatment among differing gestational age groups.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!