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| http://dx.doi.org/10.4103/IJPSYM.IJPSYM_157_17 | DOI Listing |
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Clozapine-induced agranulocytosis is documented in multiple studies, but there is limited literature on treatment-resistant agranulocytosis, the synergistic effect of multiple agranulocytosis-inducing drugs, and lithium's promyelocytic effects. This case highlights these gaps by discussing a patient with an absolute neutrophil count of zero while being treated with Depakote, Haldol, and clozapine. This case proposes more research on lithium's promyelocytic effects, especially in patients who are unresponsive or have a delayed response to discontinuing offending agents and granulocyte colony-stimulating factor (G-CSF).
View Article and Find Full Text PDFSlower clozapine titration is associated with delayed onset of clozapine-induced fever among Japanese patients with schizophrenia.
Schizophrenia (Heidelb)
November 2023
Department of Psychiatry, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan.
Clozapine-induced fever marks the beginning of its inflammatory and potentially life-threatening adverse effects, such as myocarditis. We retrospectively analyzed the correlation between clozapine titration rate and fever onset date in 254 Japanese patients, including 55 with treatment-resistant schizophrenia who developed clozapine-induced fever. Pearson's product-moment correlation indicated a significant delay in the fever onset date with slower titration.
View Article and Find Full Text PDFClozapine-Induced Eosinophilia: a Case Report.
Rev Colomb Psiquiatr (Engl Ed)
November 2023
Psychiatry and Mental Health Department of Hospital Senhora da Oliveira, Guimarães, Portugal.
Introduction: Clozapine is an atypical antipsychotic drug eligible for treatment-resistant schizophrenia. It frequently represents the best and the only choice in resistant schizophrenia. However, its use is feared by many professionals due to its possible adverse effects, such as eosinophilia.
View Article and Find Full Text PDFDelayed Fibrosis and Late Course Magnetic Resonance Imaging Findings in Clozapine-Induced Myocarditis in an Adolescent.
J Child Adolesc Psychopharmacol
May 2023
Division of Child Psychiatry, Department of Psychiatry, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
Pharmacogenomics of Clozapine-induced agranulocytosis: a systematic review and meta-analysis.
Pharmacogenomics J
July 2022
Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Although clozapine is the most effective pharmacotherapy for treatment-resistant schizophrenia, it is under-utilized, and initiation is often delayed. One reason is the occurrence of a potentially fatal adverse reaction, clozapine-induced agranulocytosis (CIA). Identifying genetic variations contributing to CIA would help predict patient risk of developing CIA and personalize treatment.
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