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| http://dx.doi.org/10.3324/haematol.2017.165282 | DOI Listing |
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Optimized BCMA/CS1 bispecific TRuC-T cells secreting IL-7 and CCL21 robustly control multiple myeloma.
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Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, China.
Introduction: Challenges remain in reducing antigen escape and tumor recurrence while CAR-T cell therapy has substantially improved outcomes in the treatment of multiple myeloma. T cell receptor fusion construct (TRuC)-T cells, which utilize intact T cell receptor (TCR)-CD3 complex to eliminate tumor cells in a non-major histocompatibility complex (MHC)-restricted manner, represent a promising strategy. Moreover, interleukin-7 (IL-7) is known to enhance the proliferation and survival of T cells.
View Article and Find Full Text PDFThe continually evolving landscape of novel therapies in oncogene-driven advanced non-small-cell lung cancer.
Ther Adv Med Oncol
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Cross Cancer Institute, University of Alberta, Edmonton, AB, Canada.
Non-small-cell lung cancer (NSCLC) is a highly heterogeneous disease that is frequently associated with a host of known oncogenic alterations. Advances in molecular diagnostics and drug development have facilitated the targeting of novel alterations such that the majority of NSCLC patients have driver mutations that are now clinically actionable. The goal of this review is to gain insights into clinical research and development principles by summary, analysis, and discussion of data on agents targeting known alterations in oncogene-driven, advanced NSCLC beyond those in the and the .
View Article and Find Full Text PDFWhen group grievances become personal: The neural correlates of group and personal rejection.
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Witnessing rejection against one's group can have similar impacts on psychological distress and aggression as experiencing rejection personally. In this study, we investigated the neural activity patterns of group rejection and whether they resemble those of personal-level rejection. We first identified the neural correlates of social rejection (exclusion based on negative attention) compared with ostracism (exclusion based on lack of social connection) and then compared group-level to personal-level rejection.
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The Higher Educational Key Laboratory for Flexible Manufacturing Equipment Integration of Fujian Province (Xiamen Institute of Technology), Xiamen, 361021, China.
With ongoing social progress, three-dimensional (3D) video is becoming increasingly prevalent in everyday life. As a key component of 3D video technology, depth video plays a crucial role by providing information about the distance and spatial distribution of objects within a scene. This study focuses on deep video encoding and proposes an efficient encoding method that integrates the Convolutional Neural Network (CNN) with a hyperautomation mechanism.
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