AI Article Synopsis
- Antimicrobial textile products, particularly those using silver nanoparticles (AgNPs), are emerging as significant functional textiles, but their effects on health are still being studied.
- Exposure to AgNPs in zebrafish embryos was evaluated for impacts on biological pathways, including Wnt signaling and cell proliferation, using various biochemical and histological methods.
- The study found that AgNP exposure led to increased oxidative stress, apoptosis, and altered expression of cell cycle and proliferation markers, suggesting potential toxic effects.
Article Abstract
Antimicrobial textile products are developing rapidly as an important part of functional textiles. Silver nanoparticles (AgNPs) are nanotechnology products with antimicrobial properties. However, exposure to nanoparticles in daily life is an important issue for public health, still being updated. Aim was to evaluate the effects of AgNPs on the development of zebrafish embryos focusing on Wnt pathway, proliferation, oxidant-antioxidant status, and apoptosis. The expressions of ccnd1 and gsk3β were determined by RT-PCR, whereas β-catenin and proliferative cell antigen (PCNA) expressions were determined immunohistochemically. Lipid peroxidation, superoxide dismutase, and glutathione-S-transferase activities were determined spectrophotometrically. Apoptosis was determined using acridine orange staining. Oxidant status, apoptosis, immunohistochemical PCNA, and β catenin staining increased, whereas ccnd1 and antioxidant enzyme activities decreased in AgNPs-exposed embryos in a dose-dependent manner. Our results indicate the interaction of possible mechanisms that may be responsible for the toxic effects of AgNPs in zebrafish embryos.
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| http://dx.doi.org/10.1002/jbt.22015 | DOI Listing |
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