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Development and optimization of an in vitro release assay for evaluation of liposomal irinotecan formulation.
Int J Pharm
December 2024
Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI 48109, United States; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, United States. Electronic address:
Onivyde®, a pegylated irinotecan liposomal formulation, is approved by the USFDA for treating metastatic pancreatic adenocarcinoma. Despite the substantial interest in developing its generic versions, the unique structural and manufacturing complexities of liposomal formulations pose challenges. In this study, we address this gap by developing a robust in vitro release test (IVRT) using dialysis membrane techniques.
View Article and Find Full Text PDFTOBE-Costas Arrays for Fast High-Resolution 3-D Power Doppler Imaging.
IEEE Trans Ultrason Ferroelectr Freq Control
June 2024
Two-dimensional sparse arrays and row-column arrays are both alternatives to 2-D fully addressed arrays with lower channel counts. Row-column arrays have recently demonstrated fast 3-D structural and flow imaging but commonly suffer from high grating lobes or require multiplexing to achieve better quality. Two-dimensional sparse arrays enable full-volume acquisitions for each transmit event, but plane-wave transmissions with them usually lack quality in terms of uniformity of wavefronts.
View Article and Find Full Text PDFStudy of diminutive granules as feed powders for manufacturability of high drug load minitablets.
Int J Pharm
May 2023
GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore. Electronic address:
The maximal amount of drug contained in a minitablet is limited. To reduce the total number of minitablets in a single dose, high drug load minitablets can be prepared from high drug load feed powders by various pharmaceutical processing techniques. Few researchers have however examined the influence of pharmaceutical processing techniques on the properties of high drug load feed powders, and consequently the manufacturability of high drug load minitablets.
View Article and Find Full Text PDFThe determinants of the quality of clinical management among diabetic and hypertensive patients in a context of fragility: A cross-sectional survey from Lebanon.
Front Public Health
August 2022
College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.
Introduction: The management of NCDs is a growing challenge in low- and middle-income settings with the increasing prevalence and the associated demands that such conditions make on health systems. Fragile settings both exacerbate the risk of NCDs and undermine systems capacity. Lebanon is a setting where strategies to address rising NCDs burden have faced particularly acute contextual challenges.
View Article and Find Full Text PDFDevelopment of a tablet press feed frame lead lag determination model using in-line and off-line NIR measurements.
Int J Pharm
January 2022
Ghent University, Laboratory of Pharmaceutical Process Analytical Technology, Ottergemsesteenweg 460, Gent 9000, Belgium.
For continuous pharmaceutical manufacturing of oral solid dosages, it is essential that product quality is measured inline. In this application, a continuous rotary tablet press is used. The goal is a model-based assessment of the quality of the blend in the feed frame to determine whether the concentration of the active pharmaceutical ingredient (API) will be within the prescribed limits.
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