The Mel strain of can reduce the permissiveness of mosquitoes to disseminated arboviral infections. Here, we report that Mel-infected (Ho Chi Minh City background), when directly blood-fed on 141 viremic dengue patients, have lower dengue virus (DENV) transmission potential and have a longer extrinsic incubation period than their wild-type counterparts. The Mel-infected mosquitoes that are field-reared have even greater relative resistance to DENV infection when fed on patient-derived viremic blood meals. This is explained by an increased susceptibility of field-reared wild-type mosquitoes to infection than laboratory-reared counterparts. Collectively, these field- and clinically relevant findings support the continued careful field-testing of Mel introgression for the biocontrol of -born arboviruses.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777059 | PMC |
| http://dx.doi.org/10.1073/pnas.1715788115 | DOI Listing |
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