Cystic echinococcosis/hydatidosis is an important cosmopolitan zoonotic disease that causes large economic losses and human suffering. The larval stages of Echinococcus granulosus are the etiological agents of cystic echinococcosis that showed different genotypes in different regions in the world. The present study was aimed at the detection of E. granulosus strains circulating in two cities from north of Iraq (Kirkuk and Sulaimania). A total of 47 specimens of hydatid cysts were collected from patients and from different domestic intermediate hosts including cattle, sheep, goat and buffalo from slaughterhouses. Molecular characterization was performed by direct sequencing of the mitochondrial DNA (mtDNA) genes coding for the cytochrome c oxidase I (cox1) and the small subunit ribosomal RNA (rrnS). The results showed a high prevalence for the sheep strain (G1), an isolated finding of the buffalo strain (G3) and the presence of seven and three different microvariants for cox1 and rrnS, respectively. This is the first contribution on molecular genotyping of E. granulosus in Iraq with the observation of genotypes other than G1.
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http://dx.doi.org/10.1016/j.vetpar.2017.11.010 | DOI Listing |
Genome-wide association studies (GWAS) have identified genetic variants robustly associated with asthma. A potential near-term clinical application is to calculate polygenic risk score (PRS) to improve disease risk prediction. The value of PRS, as part of numerous multi-source variables used to define asthma, remains unclear.
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January 2025
School of BioSciences, The University of Melbourne, Royal Parade, Parkville, VIC 3010, Australia.
Genomic prediction applies to any agro- or ecologically relevant traits, with distinct ontologies and genetic architectures. Selecting the most appropriate model for the distribution of genetic effects and their associated allele frequencies in the training population is crucial. Linear regression models are often preferred for genomic prediction.
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January 2025
Julius Kühn Institute (JKI), Federal Research Centre for Cultivated Plants, Institute for Breeding Research on Fruit Crops, Pillnitzer Platz 3a, 01326, Dresden-Pillnitz, Germany.
The German Fruit Genebank is a decentralized network focused on coordinating various germplasm collections across Germany to conserve and utilize the genetic resources of native fruit species. This aim emphasizes the necessity of trueness-to-type validation of genetic resources based on pomological and molecular characteristics. Between 2009 and 2021, multiple projects were undertaken to create an inventory of the apple (Malus ssp.
View Article and Find Full Text PDFPlant Physiol Biochem
January 2025
Department of Agriculture, Food and Environment, University of Pisa, Italy; Centre of Agro-Ecological Research "Enrico Avanzi" (CiRAA), Pisa, Italy.
Tomato (Solanum lycopersicum L.) is a major crop in the Mediterranean basin, vulnerable to drought at any crop stage. Landraces are traditional, locally adapted varieties with greater resilience to water scarcity than modern cultivars.
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January 2025
Center for Spatial and Functional Genomics, The Children's Hospital of Philadelphia, Philadelphia, United States.
The prevalence of childhood obesity is increasing worldwide, along with the associated common comorbidities of type 2 diabetes and cardiovascular disease in later life. Motivated by evidence for a strong genetic component, our prior genome-wide association study (GWAS) efforts for childhood obesity revealed 19 independent signals for the trait; however, the mechanism of action of these loci remains to be elucidated. To molecularly characterize these childhood obesity loci, we sought to determine the underlying causal variants and the corresponding effector genes within diverse cellular contexts.
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