Background: Daily living requires the ability to perform dual-tasking. As cognitive skills decrease in dementia, performing a cognitive and motor task simultaneously become increasingly challenging and subtle gait abnormalities may even be present in pre-dementia stages. Therefore, a dual-tasking paradigm, such as the Timed Up and Go-Dual Task (TUG-DT), may be useful in the diagnostic assessment of mild cognitive impairment (MCI).
Objective: To investigate the diagnostic and prognostic ability of a dual-tasking paradigm in patients with MCI or mild Alzheimer's disease (AD) and to evaluate the association between the dual-tasking paradigm and cerebrospinal fluid (CSF) AD biomarkers.
Methods: The study is a prospective cohort study conducted in a clinical setting in two memory clinics. Eighty-six patients were included (28 MCI, 17 AD, 41 healthy controls (HC)). The ability to perform dual-tasking was evaluated by the TUG-DT. Patients underwent a standardized diagnostic assessment and were evaluated to determine progression yearly.
Results: ROC curve analysis illustrated a high discriminative ability of the dual-tasking paradigm in separating MCI patients from HC (AUC: 0.78, AUC: 0.82) and a moderate discriminative ability in separating MCI from AD (AUC: 0.73, AUC: 0.55). Performance discriminated clearly between all groups (p < 0.01). Logistic regression analyses revealed a low prognostic value of the dual-tasking paradigm for progression and rate of cognitive decline. A moderately strong correlation between the dual-tasking paradigm and CSF AD biomarkers was observed.
Conclusion: In our study, we found that patients with MCI and mild AD have increasing difficulties in dual-tasking compared to healthy elderly. Hence, the dual-tasking paradigm may be a potential complement in the diagnostic assessment in a typical clinical setting.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3233/JAD-161310 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The costs of shifting from dual-task to single-task processing: Applying the fade-out paradigm to dual tasking.
J Exp Psychol Learn Mem Cogn
December 2024
Department of Psychology, University of Greifswald.
Cognitive control processes mirror fast and dynamic adaptation toward a change in the environment. When performing dual tasks, mental representations of dual-task-specific control requirements and the task-pair set are established that help to manage dual-task processing (Hirsch et al., 2017, 2018; Hommel, 2004, 2020).
View Article and Find Full Text PDFCortical structure of left superior parietal cortex is associated with cognition and dual tasking: A cross-sectional preliminary study between mild cognitive impairment and healthy controls.
Behav Brain Res
February 2025
Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. Electronic address:
Background: Individuals with mild cognitive impairment (MCI) exhibit poorer performance in cognition and dual-task paradigm, while the related cortical thickness and surface area alterations remains unclear.
Methods: Thirty participants with MCI and thirty healthy controls (HC) were recruited. Magnetic resonance imaging, cognitive assessments and dual-task Timed Up and Go test (DT-TUG) were performed to assess cerebral cortical thickness and surface area, cognitive functions, and dual-task cost (DTC) of the execution time in TUG.
Note on the Dual-Task Paradigm and its Use to Measure Listening Effort.
Trends Hear
October 2024
Department of Speech & Hearing Sciences, University of Washington, Seattle, WA, USA.
People regularly communicate in complex environments, requiring them to flexibly shift their attention across multiple sources of sensory information. Increasing recruitment of the executive functions that support successful speech comprehension in these multitasking settings is thought to contribute to the sense of effort that listeners often experience. One common research method employed to quantify listening effort is the dual-task paradigm in which individuals recognize speech and concurrently perform a secondary (often visual) task.
View Article and Find Full Text PDFA useful cognitive motor dual task paradigm in prodromal and manifest Huntington's disease.
Parkinsonism Relat Disord
November 2024
Department of Psychology, San Diego State University, San Diego, CA, USA; San Diego State University/UC San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
Introduction: Individuals with Huntington's disease (HD) experience increased difficulty with balance throughout disease progression. Adding a simultaneous cognitive task to a balance assessment, referred to as a dual task (DT) paradigm, may have a deleterious effect on balance, which can be expressed in terms of a Dual Task Cost (DTC), relative to a single task (ST) condition. The aim of this study is to explore whether a cognitive-motor DT paradigm uncovers balance deficits in prodromal (Pro-HD) and manifest HD, compared to healthy adults (HA).
View Article and Find Full Text PDFKinematic and neuromuscular characterization of cognitive involvement in gait control in healthy young adults.
J Neurophysiol
November 2024
Normandie Université, UNICAEN, INSERM, COMETE, GIP Cyceron, Caen, France.
The signature of cognitive involvement in gait control has rarely been studied using both kinematic and neuromuscular features. The present study aimed to address this gap. Twenty-four healthy young adults walked on an instrumented treadmill in a virtual environment under two optic flow conditions: normal (NOF) and perturbed (POF, continuous mediolateral pseudorandom oscillations).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!