AI Article Synopsis
- - The study focused on understanding the factors that lead to metastasis in adenoid cystic carcinoma (AdCC), a type of malignant tumor in salivary glands.
- - Researchers created three unique AdCC cell lines to investigate their characteristics, finding that the lymph node metastatic cells (ACCS-LN-GFP) showed increased expression of the enzyme NNMT, linked to tumor growth, while also decreasing the gap junction protein alpha-1.
- - The findings suggest that NNMT might serve as a useful biomarker for AdCC, indicating a mechanism where cancer stem cell traits help mediate the tumor's spread through epithelial-mesenchymal transition.
Article Abstract
Background/aim: Adenoid cystic carcinoma (AdCC) is a malignant tumor that occurs in the salivary glands and frequently metastasizes. The aim of this study was to identify factors mediating AdCC metastasis.
Materials And Methods: We established three AdCC cell lines by orthotropic transplantation and in vivo selection: parental, highly metastatic (ACCS-M-GFP), and lymph node metastatic (ACCS-LN-GFP) cells.
Results: We examined the three cell lines. DNA microarray indicated significantly altered processes in ACCS-LN-GFP cells: particularly, the expression of nicotinamide N-methyltransferase (NNMT) was enhanced the most. NNMT is associated with tumorigenesis and is a potential tumor biomarker. Concomitantly, we found-significant down-regulation of gap junction protein alpha-1. We suggest that ACCS-LN-GFP cells acquire cancer stem cell features involving the up-regulation of NNMT and the loss of gap junction protein alpha-1, leading to epithelial-mesenchymal transition and consequent AdCC metastasis.
Conclusion: NNMT is a potential biomarker of AdCC.
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| http://dx.doi.org/10.21873/anticanres.12207 | DOI Listing |
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