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The Role of Exosomes in Medical Dermatology: Literature Review and Update.
J Cosmet Dermatol
January 2025
Clinical Research Center of the Carolinas, Charleston, South Carolina, USA.
Background: Exosomes are extracellular vesicles, composed of a phospholipid bilayer, that are primarily derived from stem cells. The contents of exosomes can be incorporated into the tissue in which they are introduced, which presents a unique therapeutic option.
Aims: Exosomes have been investigated as a treatment for a number of medical ailments, but the literature supporting these indications is inconclusive.
Exosomal signaling in gynecologic cancer development: The role of cancer-associated fibroblasts.
Pathol Res Pract
December 2024
Pharmacy College, Al-Farahidi University, Iraq.
Gynecologic cancer, a prevalent and debilitating disease affecting women worldwide, is characterized by the uncontrolled proliferation of cells in the reproductive organs. The complex etiology of gynecologic cancer encompasses multiple subtypes, including cervical, ovarian, uterine, vaginal, and vulvar cancers. Despite optimal treatment strategies, which typically involve cytoreductive surgery and platinum-based chemotherapy, gynecologic cancer frequently exhibits recalcitrant relapse and poor prognosis.
View Article and Find Full Text PDFDiverse clinical manifestations of acquired vulvar lymphangioma: a report of five cases in Vietnamese women.
Dermatol Reports
September 2024
Ho Chi Minh City Hospital of Dermato-Venereology, Ho Chi Minh City.
Acquired vulvar lymphangioma (AVL) is a rare but important condition that requires prompt diagnosis and appropriate management to alleviate symptoms and prevent complications. AVL can erupt locally as isolated or clustered lesions which range from translucent, fluid-filled vesicles to smooth, flesh-colored papules or nodules that exude serous or crystalline liquid spontaneously or after trauma. Clinically, it can also be asymptomatic.
View Article and Find Full Text PDFThe role of extracellular vesicles in the pathogenesis of gynecological cancer.
Front Oncol
September 2024
Department of Biotechnology, Biotechnology Research and Innovation Council-National Institute of Biomedical Genomics, Kalyani, West Bengal, India.
Article Synopsis
- Gynecological cancer is the most prevalent cancer affecting women globally, primarily developing in the reproductive organs, and conventional treatments often fail.
- Recent studies show that extracellular vesicles (EVs) significantly influence the progression of various types of gynecological cancers by altering the behavior of nearby cells, making them potential biomarkers for diagnosis and prognosis.
- Targeting EVs—by focusing on their creation, content, and how they enter cells—may offer new therapeutic strategies alongside traditional treatment methods.
L1CAMs are immunoglobulin superfamily cell adhesion molecules that ensure proper nervous system development and function. In addition to being associated with the autism and schizophrenia spectrum disorders, mutations in the L1CAM family of genes also underlie distinct developmental syndromes with neurological conditions, such as intellectual disability, spastic paraplegia, hypotonia and congenital hydrocephalus. Studies in both vertebrate and invertebrate model organisms have established conserved neurodevelopmental roles for L1CAMs; these include axon guidance, dendrite morphogenesis, synaptogenesis, and maintenance of neural architecture, among others.
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