Genetic factors are involved in the predisposition to alcohol dependence with an heritability of about 0.5. Sequencing or analysis of the polymorphisms of genes or the whole human genome allow to identify genetic markers of alcohol dependence. Genes of the brain pathway of motivation and reward, including DRD2 and ANKK1, are associated with alcohol dependence. Genes encoding the gabaergic receptors show variants link to alcohol dependence. Polymorphisms in the genes encoding the enzymes alcohol desydrogenases (ADH) and aldehyde-dehydrogenases (ALDH) are associated to the susceptibility or the protection of alcohol dependence. Interaction between genes and environment, via the epigenetics, influence the predisposition to alcohol dependence.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.lpm.2017.07.007 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Genetic associations between orexin genes and phenotypes related to behavioral regulation in humans, including substance use.
Mol Psychiatry
January 2025
Department of Psychiatry, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, 08854, USA.
The hypothalamic neuropeptide system of orexin (hypocretin) neurons provides projections throughout the neuraxis and has been linked to sleep regulation, feeding and motivation for salient rewards including drugs of abuse. However, relatively little has been done to examine genes associated with orexin signaling and specific behavioral phenotypes in humans. Here, we tested for association of twenty-seven genes involved in orexin signaling with behavioral phenotypes in humans.
View Article and Find Full Text PDFDisulfiram-Loaded PLGA nanoparticles modified with a Phenyl borate chitosan Conjugate enhance hepatic carcinoma treatment.
Int J Pharm
January 2025
Center for New Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou 510006 China; Guangdong Provincial Key Laboratory for Research and Evaluation of Pharmaceutical Preparations, Guangdong Pharmaceutical University, Guangzhou 510006 China; Guangdong Provincial Engineering Center of Topical Precision Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou 510006 China. Electronic address:
Disulfiram (DSF), which has been traditionally used to treat alcoholism, has been shown to inhibit tumor growth, indicating its potential as an anticancer agent. However, its development and application are hindered by its poor water solubility, instability in physiological environments, and low bioavailability. In this study, phenylboronic acid-chitosan (PBA-CS) grafts were synthesized using the carbodiimide method.
View Article and Find Full Text PDFBetween the streets and the RAPS: Integrative review on the access of the homeless population to Mental Health Services.
Cien Saude Colet
January 2025
Instituto René Rachou, Fundação Oswaldo Cruz (Fiocruz Minas). Av. Augusto de Lima 1715, Barro Preto. 30190-002 Belo Horizonte MG Brasil.
This integrative review systematized the factors that influence access to mental health services for the Homeless Population (HP) in harmful use of alcohol and other drugs in the Psychosocial Care Network (RAPS) in Brazil by categorizing the factors into access "barriers" and "facilitators". We selected 13 corresponding articles and subsequently assessed their methodological quality. We identified 19 access barriers and 22 access facilitators, observing a convergence and complementarity of the factors identified, with no disagreements between authors.
View Article and Find Full Text PDFImpact of Ligand-Induced Oligomer Dissociation on Enzyme Diffusion, Directly Observed at the Single-Molecule Level.
Nano Lett
January 2025
Chemical Biology 1, University of Groningen, Nijenborgh 7, 9747 AG Groningen, The Netherlands.
The existence of the phenomenon of enhanced enzyme diffusion (EED) has been a topic of debate in recent literature. One proposed mechanism to explain the origin of EED is oligomeric enzyme dissociation. We used mass photometry (MP), a label-free single-molecule technique, to investigate the dependence of the oligomeric states of several enzymes on their ligands.
View Article and Find Full Text PDFA case of bacteremia in a 38-year-old homeless male originating from a maggot-infested amputated foot.
IDCases
January 2025
University of Kansas Medical Center, Department of Internal Medicine, Division of Infectious Diseases, 3901 Rainbow Blvd., Mailstop 1028, Kansas City, KS 66160, USA.
() was first isolated from the larval stage of the fly vector It is a gram-negative, non-motile, strictly aerobic rod that thrives in temperatures between 28º C and 37º C. Its strong chitinase activity aids in metamorphosis, which suggests a symbiotic relationship with the fly. Although rare, has been implicated in human infections, like bacteremia and osteomyelitis, typically transmitted through fly larvae in skin wounds.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!