The rapid development and widespread applications of nanotechnology necessitates the design towards safe nanoparticles. Surface structure is among the most important physicochemical characteristics of metallic nanoparticles affecting their mode of action in certain biological or environmental compartments. This study aimed to investigate how different surface coatings affect the cytotoxicity and cellular uptake of silver nanoparticles (AgNPs) in murine neural stem cells (mNSCs). Different AgNPs were prepared by stabilisation with surface coatings encompassing sodium bis(2-ethylhexyl)-sulfosuccinate (AOT), cetyltrimethylammonium bromide (CTAB), poly(vinylpyrrolidone) (PVP), poly-l-lysine (PLL), and bovine serum albumin (BSA). The obtained results revealed that AgNPs stabilized with different surface coating caused different cytotoxicity effects and internalization pattern in mNSCs. Macropinocytosis was determined as the main uptake mechanism in mNSCs for all of the tested AgNP types. These findings contribute to the overall knowledge essential to the safety assessment of novel nanomaterials.
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