A new pentacyclic guanidine alkaloid, monanchoxymycalin C () was isolated from a new collection of marine sponge along with the known monanchoxymycalin A (). The structure of was elucidated on the basis of spectroscopic data. Monanchoxymycalin C exhibits cytotoxic activity against human cancer HeLa cells at low micromolar concentrations, induces apoptosis-related death of malignant cells and inhibits cancer cell colony formation. In addition, synergistic and additive effects have been observed in combination with cisplatin.
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