PET imaging with Ga-labeled tracers has seen a dramatic increase over the past five years primarily due to the increased accessibility of Ge/Ga generators, the availability of tracers with superb targeting properties for labeling, straightforward labeling procedures and the approval of these tracers by regulatory entities. Available Ge/Ga generators nominally deliver up to 1.85 GBq (50mCi) when fresh limiting production and distribution of Ga-labeled tracers to a few daily doses per generator. The focus of this study was to provide a simple and efficient method for Ga production in clinically relevant quantities using a low energy medical cyclotron with a solid target.
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http://dx.doi.org/10.1016/j.apradiso.2017.12.010 | DOI Listing |
Mol Neurobiol
January 2025
Translational Oncology Laboratory, Department of Zoology, Hansraj College, Delhi University, New Delhi, 110007, India.
This review explores the current understanding and recent advancements in neuroblastoma, one of the most common extracranial solid pediatric cancers, accounting for ~ 15% of childhood cancer-related mortality. The hallmarks of NBL, including angiogenesis, metastasis, apoptosis resistance, cell cycle dysregulation, drug resistance, and responses to hypoxia and ROS, underscore its complex biology. The tumor microenvironment's significance in disease progression is acknowledged in this study, along with the pivotal role of cancer stem cells in sustaining tumor growth and heterogeneity.
View Article and Find Full Text PDFSleep
January 2025
UR2NF-Neuropsychology and Functional Neuroimaging Research Unit affiliated at CRCN - Centre for Research in Cognition and Neurosciences and UNI - ULB Neuroscience Institute, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Enhancing the retention of recent memory traces through sleep reactivation is possible via Targeted Memory Reactivation (TMR), involving cueing learned material during post-training sleep. Evidence indicates detectable short-term microstructural changes in the brain within an hour after motor sequence learning, and post-training sleep is believed to contribute to the consolidation of these motor memories, potentially leading to enduring microstructural changes. In this study, we explored how TMR during post-training sleep affects performance gains and delayed microstructural remodeling, using both standard Diffusion Tensor Imaging (DTI) and advanced Neurite Orientation Dispersion & Density Imaging (NODDI).
View Article and Find Full Text PDFIndian J Nucl Med
November 2024
Health Physics Division, Bhabha Atomic Research Centre, Mumbai, Maharashtra, India.
Over the last 15 years, there has been substantial growth in the installation of medical cyclotrons. This is mainly due to the increased demand for the production of positron emission tomography radiopharmaceuticals. In every country, there is a regulatory body that regulates the uses of medical cyclotron intending to protect occupational workers, the public, and the environment.
View Article and Find Full Text PDFIndian J Nucl Med
November 2024
Department of Nuclear Medicine and Molecular Imaging, Homi Bhabha Cancer Hospital & Mahamana Pandit Madan Mohan Malaviya Cancer Centre, Tata Memorial Centre, Homi Bhabha National Institute (HBNI), Varanasi, India.
Background: The introduction of positron emission tomography/computed tomography (PET/CT) has significantly advanced medical imaging. In oncology, F-fluorodeoxyglucose (F-FDG) PET/CT is particularly crucial for staging, evaluating treatment response, monitoring follow-up, and planning radiotherapy. However, in resource limiting hospitals, the availability of fluorine-labeled F-FDG limits optimal scan acquisition.
View Article and Find Full Text PDFAppl Radiat Isot
December 2024
National Centre for Physics, Quaid-i-Azam University Campus Islamabad, Pakistan.
Cd (T = 6.5 h) and Cd (T = 461.9 d) are promising non-standard gamma-emitting radionuclides with significant potential for SPECT use.
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