AI Article Synopsis
- - The adult adaptive immune system consists of various lymphocyte subsets that work together to provide effective immune protection and self-regulation, each with unique characteristics and functions.
- - Some lymphocytes are continuously replenished by stem cells in the bone marrow, while others are generated during specific periods in early life and then maintain their populations through self-renewal.
- - The review highlights recent findings on how developmental timing influences the production of B cells in mice and discusses age-specific factors that contribute to the diversity of the adaptive immune system.
Article Abstract
The adult adaptive immune system is comprised of a wide spectrum of lymphocyte subsets with distinct antigen receptor repertoire profiles, effector functions, turnover times and anatomical locations, acting in concert to provide optimal host protection and self-regulation. While some lymphocyte populations are replenished by bone marrow hematopoietic stem cells (HSCs) through adulthood, others emerge during a limited window of time during fetal and postnatal life and sustain through self-replenishment. Despite fundamental implications in immune regeneration, early life immunity and leukemogenesis, the impact of developmental timing on lymphocyte output remains an under explored frontier in immunology. In this review, we spotlight recent insights into the developmental changes in B cell output in mice and explore how several age specific cellular and molecular factors may shape the formation of a diverse adaptive immune system.
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| http://dx.doi.org/10.1016/j.coi.2017.12.005 | DOI Listing |
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