AI Article Synopsis
- The study examined how purinergic P2 receptors affect blood vessel dilation in the skin of young adults, both at rest and during moderate exercise in hot conditions (35 °C).
- Blocking P2 receptors increased blood vessel dilation when the subjects were resting, but this effect was not observed during or after exercise.
- The increased dilation at rest was partially reduced when nitric oxide production was inhibited, indicating that P2 receptors play a role in managing blood flow in the heat.
Article Abstract
We assessed the role of purinergic P2 receptors in the regulation of cutaneous vasodilation in young adults at rest and during intermittent moderate-intensity exercise in the heat (35 °C). P2 receptor blockade augmented resting cutaneous vasodilation but had no influence during and following exercise. This increase was partly diminished by nitric oxide synthase inhibition. These results suggest a functional role of P2 receptors in the regulation of cutaneous vascular tone during ambient heat exposure at rest.
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| http://dx.doi.org/10.1139/apnm-2017-0700 | DOI Listing |
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