In brief When active patients relate brief chronic fatigue, three basic questions must be answered: Is there an underlying medical or psychiatric disorder? Could the fatigue be from overtraining or a sleep disturbance? Does the patient have chronic fatigue syndrome or the far more common idiopathic chronic fatigue? Answers may come from sensitive history-taking and targeted physical and laboratory exams. And the patient must play an active role in treatment, which includes reassurance, stress relief, and regular exercise.
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Ex vivo electrophysiological evaluation of peripheral nerve functioning following exposition of adult mice to the organophosphorus pesticide chlormephos.
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Université Paris-Saclay, CEA, Institut des sciences du vivant Frédéric Joliot, Département Médicaments et Technologies pour la Santé (DMTS), Service d'Ingénierie Moléculaire pour la Santé (SIMoS), EMR CNRS/CEA 9004, 91191 Gif-sur-Yvette, France. Electronic address:
The organophosphorus pesticide chlormephos was tested for its potential peripheral neurotoxicity by analyzing the diphasic compound action potential (CAP) of sciatic nerves isolated from adult mice chronically exposed to a sub-lethal dose of this pesticide, compared with control age-matched animals being only exposed to the vehicle. No significant modification was detected between chlormephos-exposed and control groups in their nerve responsiveness to stimulus. Furthermore, similar values of CAP kinetic variables were obtained from the two mouse groups.
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West China School of Public Health and West China Fourth Hospital, West China Nursing School, Sichuan University, Chengdu 610041, China. Electronic address:
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