We introduce a new strategy for synthesis of chiral amines: couplings of α-aminoalkyl nucleophiles generated by enantioselective migratory insertion of 2-azadienes to a Cu-H. In this report, we demonstrate its application in catalytic reductive coupling of 2-azadienes and ketones to furnish 1,2-amino tertiary alcohols with vicinal stereogenic centers.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936605 | PMC |
| http://dx.doi.org/10.1021/jacs.7b12213 | DOI Listing |
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