Problem: Breastfeeding's influence on the tolerance to environmental antigens is essential for short- and long-term homeostasis for children. Colostrum is rich in leucocytes, but it is unknown whether regulatory T cells (Treg) account for part of this cell population.
Method Of Study: Frequencies of CD127 CD25 Treg and levels of immunoregulatory-associated cell markers were determined in colostrum and were compared with autologous blood cells. In addition, we evaluated whether the birth conditions can affect these features.
Results: Higher frequencies of CD127 CD25 Treg cells expressing Foxp3 and CD45RO were observed in the colostrum. The cells' CD25, CD152, CD279, and TGF-β expression levels were greater than those in autologous blood cells. In addition, the CD279 and TGF-β expressions of colostrum CD127 CD25 Treg cells were influenced by gestational age and delivery mode.
Conclusion: The higher proportion of these cells with a function-associated phenotype may reflect certain tolerogenic effects of breastmilk on newborns and infants, contributing to immune system homeostasis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/aji.12806 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Causal role of immune cells in aplastic anemia: Mendelian randomization (MR) study.
Sci Rep
August 2024
Department of Hematology, The First Hospital of Jilin University, Changchun, China.
Prior research has identified associations between immune cells and aplastic anaemia (AA); however, the causal relationships between them have not been conclusively established. A two-sample Mendelian randomisation analysis was conducted to investigate the causal link between 731 immune cell signatures and AA risk using publicly available genetic data. Four types of immune signatures, including relative cell, absolute cell (AC), median fluorescence intensities and morphological parameters, were considered sensitivity analyses were also performed to verify the robustness of the results and assess potential issues such as heterogeneity and horizontal pleiotropy.
View Article and Find Full Text PDFCD4+CD25+CD127FOXP3+ cell in food allergy: Does it predict anaphylaxis?
Allergol Immunopathol (Madr)
June 2023
Department of Pediatric Allergy and Immunology, Dr Behcet Uz Children's Hospital, Izmir, Turkey.
Background: Food allergy (FA), hence the incidence of food anaphylaxis, is a public health problem that has increased in recent years. There are still no biomarkers for patients with FA to predict severe allergic reactions such as anaphylaxis.
Objective: There is limited information on whether regulatory T (Treg) cell levels are a biomarker that predicts clinical severity in cases presenting with FA, and which patients are at a greater risk for anaphylaxis.
ICOS follicular regulatory T cells are implicated in the pathogenesis of ulcerative colitis.
Clin Exp Pharmacol Physiol
November 2021
Department of Urology, The First Affiliated Hospital of Northwest Minzu University Ningxia People's Hospital, Yinchuan, China.
Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) with a rising incidence worldwide. The precise aetiology is unclear, but aberrant regulatory T cell (Treg) responses have been documented in active UC patients. Follicular regulatory T cell (Tfr) is a recently identified subset of Treg cells.
View Article and Find Full Text PDFCase Report: Apremilast for Therapy-Resistant Pemphigus Vulgaris.
Front Immunol
July 2021
Department of Dermatology, Venereology and Allergology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Background: In pemphigus, elucidating the disease-causing immune mechanism and developing new therapeutic strategies are needed. In this context, the second messenger 3',5'-cyclic adenosine monophosphate (cAMP) is gaining attention. cAMP is important in hematological and auto-inflammatory disorders.
View Article and Find Full Text PDFA single-nucleotide polymorphism in the human ENTPD1 gene encoding CD39 is associated with worsened graft-versus-host disease in a humanized mouse model.
Immunol Cell Biol
May 2020
Illawarra Health and Medical Research Institute, Wollongong, NSW, 2522, Australia.
Regulatory T cells (Tregs) protect against graft-versus-host disease (GVHD), a life-threatening complication of allogeneic hematopoietic stem cell transplantation. The ectoenzyme CD39 is important for increasing the immunosuppressive function of Tregs. The rs10748643 (A → G) single-nucleotide polymorphism (SNP) in intron 1 of the human ENTPD1 gene is associated with increased proportions of CD39 Tregs.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!