Since the discovery of neural stem cells(NSCs) in embryonic and adult mammalian central nervous systems, new approaches for proliferation and differentiation of NSCs have been put forward. One of the approaches to promote the clinical application of NSCs is to search effective methods to regulate the proliferation and differentiation. This problem is urgently to be solved in the medical field. Previous studies have shown that traditional Chinese medicine could promote the proliferation and differentiation of NSCs by regulating the relevant signaling pathway in vivo and in vitro. Domestic and foreign literatures for regulating the proliferation and differentiation of neural stem cells in recent 10 years and the reports for their target and signaling pathways were analyzed in this paper. Traditional Chinese medicine could regulate the proliferation and differentiation of NSCs through signaling pathways of Notch, PI3K/Akt, Wnt/β-catenin and GFs. However, studies about NSCs and traditional Chinese medicine should be further deepened; the mechanism of multiple targets and the comprehensive regulation function of traditional Chinese medicine should be clarified.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.19540/j.cnki.cjcmm.20170928.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Exploring the druggability of the UEV domain of human TSG101 in search for broad-spectrum antivirals.
Protein Sci
January 2025
Department of Physical Chemistry, Institute of Biotechnology, and Unit of Excellence in Chemistry Applied to Biomedicine and Environment, School of Sciences, University of Granada, Granada, Spain.
The ubiquitin E2 variant domain of TSG101 (TSG101-UEV) plays a pivotal role in protein sorting and virus budding by recognizing PTAP motifs within ubiquitinated proteins. Disruption of TSG101-UEV/PTAP interactions has emerged as a promising strategy for the development of host-oriented broad-spectrum antivirals with low susceptibility to resistance. TSG101 is a challenging target characterized by an extended and flat binding interface, low affinity for PTAP ligands, and complex binding energetics.
View Article and Find Full Text PDFS100-positive stroma in salivary gland basal cell adenomas: a neoplastic component with CTNNB1 mutations.
Virchows Arch
December 2024
Division of Translational Oncoimmunology, Aichi Cancer Center Research Institute, Nagoya, Japan.
Basal cell adenomas (BCAs) are benign epithelial tumors of the salivary gland, characterized by the proliferation of basaloid and luminal cells. In addition, a distinctive spindle cell stroma, that is immunohistochemically-positive for S100, is often observed in BCAs. Based on the ultrastructural findings, the S100-positive stroma was presumed to originate from neoplastic myoepithelial cells.
View Article and Find Full Text PDFPhotoelectron Therapy Preventing the Formation of Bacterial Biofilm on Titanium Implants.
Small
December 2024
School of Chemical Engineering, Sichuan University, No 24th, South Section 1, Yihuan Road, Chengdu, Sichuan, 610065, China.
The exogenous bacterial infection and formation of biofilm on the surface of titanium implants can affect the adhesion, proliferation, and differentiation of cells associated with osteogenesis, ultimately leading to surgical failure. This study focuses on two critical stages for biofilm formation: i) bacterial adhesion and aggregation, ii) growth and proliferation. The titanium with well-organized titania nanotube arrays is first modified by nitrogen dopants, then loaded with CuFeSe nanoparticles to form a p-n heterojunction.
View Article and Find Full Text PDFAn Antifreezing Scaffold-Based Cryopreservation Platform of Stem Cells for Convenient Application in Wound Repair.
Adv Healthc Mater
December 2024
School of Life Science, Zhengzhou University, Zhengzhou, 450001, P. R. China.
Efficient cryopreservation of stem cells is crucial to fabricating off-the-shelf cell products for tissue engineering and regeneration medicine. However, it remains challenging due to utilization of toxic cryoprotectants for reducing ice-related cryodamages to stem cells during freeze-thaw cycle, stringent post-thaw washing process, and further integration of stem cells with scaffolds to form tissue engineering constructs for downstream applications. Herein, a novel cryopreservation platform of stem cells based on an antifreezing polyvinylpyrrolidone/gellan gum/gelatin (PGG) scaffold together is reported with an L-proline assisted cell pre-dehydration strategy.
View Article and Find Full Text PDFTargeting Remyelination in Spinal Cord Injury: Insights and Emerging Therapeutic Strategies.
CNS Neurosci Ther
December 2024
Central Laboratory of The Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital, Lishui, Zhejiang, China.
Article Synopsis
- Spinal cord injury (SCI) is a major neurological disorder causing serious motor, sensory, and autonomic issues, primarily due to poor axon regeneration and remyelination.
- Recent research highlights new therapeutic strategies that target key molecules and pathways to enhance myelin repair in SCI, using both lab and animal studies.
- The review emphasizes the challenges in applying these findings to clinical settings, focusing on safety and delivery methods, while positing targeted remyelination therapies as a hopeful treatment approach for SCI.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!