Kainate receptors (KARs) are glutamate-gated ion channels that play fundamental roles in regulating neuronal excitability and network function in the brain. After being cloned in the 1990s, important progress has been made in understanding the mechanisms controlling the molecular and cellular properties of KARs, and the nature and extent of their regulation of wider neuronal activity. However, there have been significant recent advances towards understanding KAR trafficking through the secretory pathway, their precise synaptic positioning, and their roles in synaptic plasticity and disease. Here we provide an overview highlighting these new findings about the mechanisms controlling KARs and how KARs, in turn, regulate other proteins and pathways to influence synaptic function.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420428 | PMC |
| http://dx.doi.org/10.1007/s11064-017-2450-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Divergent responses of plant multi-element coupling to nitrogen and phosphorus addition in a meadow steppe.
BMC Plant Biol
January 2025
Institute of Grassland Science, School of Life Sciences, Key Laboratory of Vegetation Ecology, Ministry of Education, Northeast Normal University, Changchun, China.
The intricate biogeochemical cycling of multiple elements plays a pivotal role in upholding a myriad of ecosystem functions. However, our understanding of elemental stoichiometry and coupling in response to global changes remains primarily limited to plant carbon: nitrogen: phosphorus (C: N: P). Here, we assessed the responses of 11 elements in plants from different functional groups to global changes.
View Article and Find Full Text PDFA machine learning model the prediction of athlete engagement based on cohesion, passion and mental toughness.
Sci Rep
January 2025
College of Physical Education and Health Sciences, Zhejiang Normal University, Jinhua, 321004, China.
Athlete engagement is influenced by several factors, including cohesion, passion and mental toughness. Machine learning methods are frequently employed to construct predictive models as a result of their high efficiency. In order to comprehend the effects of cohesion, passion and mental toughness on athlete engagement, this study utilizes the relevant methods of machine learning to construct a prediction model, so as to find the intrinsic connection between them.
View Article and Find Full Text PDFDevelopment and characterization of in vitro inducible immortalization of a murine microglia cell line for high throughput studies.
Sci Rep
January 2025
Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, United States.
There are few in vitro models available to study microglial physiology in a homeostatic context. Recent approaches include the human induced pluripotent stem cell model, but these can be challenging for large-scale assays and may lead to batch variability. To advance our understanding of microglial biology while enabling scalability for high-throughput assays, we developed an inducible immortalized murine microglial cell line using a tetracycline expression system.
View Article and Find Full Text PDFBio-inspired preparation of Ag NPs, rGO, and Ag/rGO nanocomposites for acoustical, antioxidant, and plant growth regulatory studies.
Sci Rep
January 2025
Department of Chemistry, Devchand College, Arjunnagar, Kolhapur, MH, 591237, India.
Acoustical properties are essential for understanding the molecular interactions in fluids, as they influence the physicochemical behavior of liquids and determine their suitability for diverse applications. This study investigated the acoustical parameters of silver nanoparticles (Ag NPs), reduced graphene oxide (rGO), and Ag/rGO nanocomposite nanofluids at varying concentrations. Ag NPs and Ag/rGO nanocomposites were synthesized via a Bos taurus indicus (BTI) metabolic waste-assisted method and characterized using advanced techniques, including XRD, TEM, Raman, DLS, zeta potential, and XPS.
View Article and Find Full Text PDFImaging flow cytometry reveals the mechanism of equine arteritis virus entry and internalization.
Sci Rep
January 2025
Department of Pathology, Division of Microbiology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, 50-375, Wroclaw, Poland.
The process of viral entry into host cells is crucial for the establishment of infection and the determination of viral pathogenicity. A comprehensive understanding of entry pathways is fundamental for the development of novel therapeutic strategies. Standard techniques for investigating viral entry include confocal microscopy and flow cytometry, both of which provide complementary qualitative and quantitative data.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!